Endocrine Abstracts

The discovery that mutations in fibroblast growth factor 23 (FGF23) cause autosomal dominant hypophosphatemic rickets transformed our understanding of phosphate homeostasis in health and disease (White et al. Nat Genet 2000). Since then, the critical role of FGF23 in mineral metabolism in chronic kidney disease has been established (Larsson et al. Kidney Int 2003; Gutierrez et al. J Am Soc Nephrol 2005). Elevated FGF23 has ...