ea0041oc5.4 | Neuroendocrinology | ECE2016
Timper Katharina
, Denson Jesse
, Steculorum Sophie Marie
, Rose-John Stefan
, Wunderlich Frank Thomas
, Bruning Jens C
Introduction: Interleukin (IL)-6 can activate signal transducer and activator of transcription (STAT)3-dependent signaling similar to leptin in neurons. Here we demonstrate that central application of IL-6 suppresses feeding and improves glucose tolerance in mice. Furthermore, we found that central IL-6 trans-signaling is enhanced in obese mice to improve anorexigenic and glucoregulatory effects of IL-6.Methods/design: Glucose tolerance and insulin sensi...