Endocrine Abstracts

Objective: To analyze the role of miRNAs previously found to be differentially expressed in patients with ACTH-dependent Cushing syndrome (CS).Materials and methods: We analyzed putative targets of three microRNAs, which were previously found to be differentially expressed in ACTH-dependent CS patients: miR-16-5p, miR-145-5p, miR-7g-5p. We used TargetScan (TS) and DIANA tools (DT) predictions.Results: We found different plasma expr...

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. It is important to closely monitor this therapy in order to minimize the risk of adverse effects.Aim: To evaluate the safety and monitoring of the GAHT in the Portuguese adult transgender populationMethods: Cross-sectional study conducted in March 2021. Data collected through an online questionnaire ...

GCMB, which is the mammalian homologue of the Drosophila gene Glial cells missing, encodes a 506 amino acid parathyroid-specific transcription factor that contains: a DNA-binding domain at residues 21–174; a predicted nuclear localization signal at residues 176–193; an inhibitory domain at residues 258–347; and two transactivation domains at residues 174–263, and residues 428–506. Mutations of GCMB, which is located on chrom...