Endocrine Abstracts

Background: Neuroglycopenic symptoms in insulinoma could persist for years before localising the source of endogenous hyperinsulinaemia. 90% of insulinomas are sporadic, solitary and < 2 cm in diameter, and can be associated with multiple endocrine neoplasia-1 (MEN-1). Insulinoma is an emerging clinical entity with a huge diagnostic challenge as tumour growth varies from months to years before tumour localisation.<p class="abstext...

Background: Neuroglycopenic symptoms in insulinoma could persist for years before localising the source of endogenous hyperinsulinaemia. 90% of insulinomas are sporadic, solitary and < 2 cm in diameter, and can be associated with multiple endocrine neoplasia-1 (MEN-1). Insulinoma is an emerging clinical entity with a huge diagnostic challenge as tumour growth varies from months to years before tumour localisation.<p class="abstext...

Background: Neuroendocrine tumors (NETs) and Adrenocortical carcinomas (ACCs) are rare and heterogeneous tumors entities. Advanced NETs and ACC own poor prognosis with less than 40% of five-year survival. There is a need for improved biomarkers to predict disease prognosis and treatment sensitivity. A broad overview of NETs and ACC genetics has never been explored.Aim: To investigate genotype–phenotype correlations on a pan-endocrine cancer level wi...

Hypoparathyroidism is a rare endocrine disorder characterized by insufficient parathyroid hormone levels in the blood, low serum calcium and elevated serum phosphate. Studies evaluating the prevalence of chronic hypoparathyroidism (cHypoPT) are limited, and it is challenging to compare prevalence estimates owing tothe rarity of the disease and the difficulty of differentiating transient from permanent or cHypoPTin secondary data analyses. PublishedcHypoPTprevalence is between ...

Aim: This study was to investigate the protective effect of grape procyanidins on ethanol and carbon tetrachloride induced cell damages in MC3T3-E1 osteoblast-like cells.Methods: Normal MC3T3-E1 osteoblast-like cells and cells damaged by ethanol or carbon tetrachloride were incubated with different doses of grape procyanidins for 24 hours. Cell TNF alpha mRNA expression and apoptotic DNA fragmentation were subsequently determined using in situ hyb...

Objective: To study the protective effect of grape procyanidins on hydrogen peroxide induced oxidative damage in MC3T3-E1 osteoblast-like cells. Methods: Cultured MC3T3-E1 Osteoblast-like cells were treated with grape procyanidins and 125 micromole per litre hydrogen peroxide for six hours. The levels of apoptosis, mitochondrial transmembrane potential and proliferation were subsequently analyzed by flow cytometry and Bio-Red model 550 instrument. Results: The proliferation le...

Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function along with thyroid autoimmunity in pregnant women during the second trimester. 1592 pregnant women were recruited from the obstetric outpatient department during the second trimester. Serum ferritin (SF) level...

Previous observational studies found associations between Helicobacter pylori infection and autoimmune thyroid diseases (AITDs), but the causal nature of this association is still uncertain. We investigated the causal effect of 6 crucial antibodies against H. pylori on AITDs using a bidirectional Mendelian randomization (MR). We found anti-H. pylori OMP significantly increased the risk of hyperthyroidism and Graves’ disease (GD). In addition, ou...

Introduction: Carney complex (CNC) is a rare multiple neoplasia syndrome characterized by pigmented lesions of the skin and mucosa in association with various endocrine and non-endocrine tumors. The disease can be inherited in an autosomal-dominant fashion or occur sporadically due to novel mutations in the PRKAR1A gene. Primary pigmented nodular adrenocortical disease (PPNAD) is a common endocrine manifestation of CNC.Case description: A 20-year-old wom...

Once daily oral prednisolone has been shown to mimic the normal circadian rhythm better than other glucocorticoids. Our advice is to take prednisolone first thing on waking and before breakfast to try to mimic the normal circadian rhythm as closely as possible. The leaflet that comes with prednisolone suggests that it should be taken with food. Enteric-coated prednisolone (EC) is believed to be kinder on the stomach, but there is no evidence for its use. We compared EC with st...