Endocrine Abstracts

Background: The gestational diabetes mellitus (GDM) is a metabolic disorder characterized by glucose intolerance in pregnant women without pre-existing diabetes, typically diagnosed in mid to late pregnancy. The global prevalence of GDM is on the rise, posing significant diagnostic and economic burdens on society and affecting the health of two generations, potentially impacting population quality. Early diagnosis or understanding of the pathophysiology of this disease in earl...

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor with an extracellular bilobed venus flytrap domain (VFTD) predicted to contain five calcium-binding sites. The major site for calcium-binding is comprised of amino acid residues that line the cleft between the two lobes of the VFTD. We investigated the structure-function relationships of VFTD CaSR mutations identified in patients with familial hypocalciuric hypercalcaemia (FHH), neonatal severe primary hyperpa...