Endocrine Abstracts

Thyroid hormone receptor a1 (TRa1) mediates the genomic action of thyroid hormone (T3). The biology of TRa1 in growth, differentiation, and development is well studied, but how TRa1 could crosstalk with key regulators involved in cancer development is largely unknown. In the present study, we used an epithelial cell line (NCM460D, referred to as 460D hereafter), established from normal human colon mucosal epithelium as a model to explore the interaction of TRa1 with the tumor ...

A new genetic disorder has recently been identified that results from mutation of THRA, encoding thyroid hormone receptor α1 (TRα1). Affected children have a high serum T3:T4 ratio, constipation and a variable intellectual deficit, but exhibit a consistently severe skeletal dysplasia. Similar to these patients, Thra1PV/+ mice harbour a mutation that disrupts the C-terminal α-helix of TRα1 and express a domi...