ea0035p947 | Steroid metabolism and action | ECE2014
Hofer Daniela
, Munzker Julia
, Zachhuber Verena
, Stiegler Philipp
, Hutz Karla
, Zigeuner Richard
, Pieber Thomas
, Muller Helmut
, Obermayer-Pietsch Barbara
Introduction: Testosterone production in male testicular cells is mainly stimulated by LH, secreted by the pituitary. Recent findings have shown significant clinical associations of vitamin D seasonal rhythms and androgens in men (Wehr et al. 2010, Nimptsch et al. 2012). We aimed to elucidate associations of vitamin D and androgen synthesis on a cellular level.Methods: Human primary testicular cells, isolated from testes of braindead donors, and a cell l...