Endocrine Abstracts

Objective: Change in somatostatinergic tone (SST) is one of the key features of acromegaly, but the effect of tumor size on SST is not clear.Design: The aim of this study was to determine how SST changes depending upon the size of GH-producing pituitary tumors.Method: GH levels of 29 patients with newly diagnosed acromegaly were measured using a 75 g oral glucose tolerance test (OGTT), an insulin tolerance test (ITT) and an octreot...

Objective: TRH induces GH secretion presumably by expression of TRH receptor dedifferentiated in pitutiary tumors, but it is not clear how the TRH elegantly stimulates GH secretion in tumoral states.Design: The aim of this study was to investigate how GH-producing pituitary adenomas respond to TRH with respect to GH secretion and how it differs according to octreotide responses and their sizes of tumor.Method: GH levels of 45 patie...

Introduction: Adrenal venous sampling (AVS) is considered the reference standard to select patients with unilateral aldosterone producing adenoma for adrenalectomy. Recent studies debated the “mandatory” need for AVS before adrenalectomy. We report our experience from a tertiary hospital in Asia on the treatment outcomes of patients with primary aldosteronism (PA) who underwent adrenalectomy without AVS compared to those who had successful AVS....

Gonadotrophins such as luteinizing hormone (LH) and human chorionic gonadotrophin (hCG) exert their actions on progesterone (P4) synthesis, at least in part, by regulating luteal cell phosphorylation via ser/thr kinases particularly cAMP-dependent protein kinase (PKA). Hence the aim of this study was to identify changes in P4 secretion and PKA expression during luteinization of human granulosa cells (GCs) in vitro. GCs, obtained from follicular asp...

Introduction: The most common cause of hyperthyroidism in Malaysia is autoimmune cause like Grave disease, or toxic multinodular goitre. Thyroid hormone resistant syndrome is a rare genetic disease which usually presented with mild hyperthyroidism clinically and biochemically it had elevated free T4 and non suppressed TSH. Inexperienced doctor will commonly mistreat patient with antithyroid medication. This is because this genetic disease is extremely rare to encountered in pr...

Introduction: Covid-19 vaccination have been introduced to reduce overall severity and mortality of COVID-19 infection. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a syndrome first described in 2011 that triggers autoimmune conditions after exposure to various adjuvants through various mechanisms. We report three cases of autoimmune thyrotoxicosis post mRNA type vaccine for COVID-19 possibly linked to adjuvants present in the vaccine....

Objective: Agranulocytosis is a rare but severe side effect of thionamide use in patients with hyperthyroidism. Treatment involves cessation of offending drug, treatment of sepsis, and the use of haematopoietic growth factors. Most patients recover uneventfully, and rarely present with further complications after treatment of the acute episode. We present a case report of suppurative lymphadenitis after treatment with granulocyte-stimulating factor (GCSF) and recovery from car...

Introduction: Hypokalemia is considered as a late manifestation of primary aldosteronism (PA), long preceded by hypertension. However, there have been reports of normotensive PA patients presenting with hypokalemia. This study aims to examine the relationship of hypokalemia and blood pressure in patients with hyperaldosteronism.Methods: A retrospective review of patients who underwent saline infusion test (SIT) from 2014 to 2016 was conducted. All patien...

AcroQoL is a very well-authenticated survey questionnaire capable of evaluating the quality of life (QoL) in acromegalic patients. This study was designed to investigate how AcroQoL of acromegalic patients in Korea would change after medical treatment with octreotide LAR. A total of 58 drug-naïve patients from 11 tertiary centers in Korea were included; all of them were prescribed with octreotide LAR 20 mg at the time of enrollment, and their QoL were evaluated with AcroQ...

Background: Fine needle aspiration biopsy (FNA) is the cornerstone of assessment of thyroid nodules. Cytological criteria for benign (THY2) and malignant (THY5) nodules are well-established and reliable. In a minority of patients cytology raises the possibility of a neoplasm (THY3) and only formal histological assesment can differentiate between benign and malignant lesions.Method: Retrospective review of histological and clinical data in a cohort of pat...