Endocrine Abstracts

Contexte: Kallmann syndrome is a rare genetic disease which can affect both men and women. It combines hypogonadotropic hypogonadism which characterised by a failure to start or to fully complete puberty naturally; olfactory disorders such hyposmia or anosmia, impaired color vision, deafness, unilateral or bilateral renal aplasia and midline anomalies.Objective: We report a case of this rare syndrome, responsible of delayed puberty view of infertility.</...

Background Insulin resistance (IR) is a state in which a given concentration of insulin produces biological effect less than expected and IR actually make up a broad clinical spectrum, including obesity, glucose intolerance, DM, and the metabolic syndrome that are associated with various endocrine, metabolic, & genetic conditions. There is an association of IR with thyroid abnormalities. Evidence for a relationship between T4 and T3 and glucose metabolism appeared over 100...

Background: Inflammatory cytokines were considered to play a determinant role in the development and progression of different microvascular diabetic complications including diabetic retinopathy. interleukin 27 (IL27) is a cytokine with dual proinflammatory/anti-inflammatory effects that mediates pathogenesis of different inflammatory diseases.Aim: To assess the serum and aqueous levels of (IL27) as proinflammatory/anti-inflammatory cytokine in diabetic p...

Introduction: The efficacy and safety of bariatric surgery (BS) are well documented, but data in our region is lacking.Aim: Analyze the long term effect of BS on obese patients in a single district hospital. Primary outcomes: –weight change 5–10 years post BS; –patient satisfaction. Secondary outcomes: weight reduction according to type of surgical procedure, sex, public/private hospital; mortality, complications....

A 28 year old man with a background of hypothyroidism presented to hospital following a collapse. He had a one week history of unrelenting vomiting with malaise. On examination, he appeared dehydrated and was profoundly hypotensive with a blood pressure of 56/25 mm Hg. General examination was otherwise unremarkable. The blood tests demonstrated acute kidney injury with serum creatinine 227 mmol/L and hyponatraemia with serum sodium 130 mmol/L. His potassium was within normal l...

A 32-year-old lady was referred to our centre with thyrotoxicosis and elevated FT4 and TSH levels. She was already on carbimazole. Interestingly, her symptoms started at childhood. She was nicknamed ‘shaky’ by her school friends because of her tremors. There was no family history of thyroid disease.She was clinically and biochemically thyrotoxic with FT4 of 12.4–38.8 pmol/l and TSH of 7.24–38.8 mIU/l.<p class...

Objective: Highlight hypertrophic pulmonary osteoarthropathy (HPOA) and partial HPOA as a cause for raised bony alkaline phosphatase (ALP).Case: We report the case of a 59-year-old lady who was referred to the endocrine clinic with 2 years history of bilateral leg pain and raised bony ALP. She denied any other symptoms. She had no past medical history. She was not on any regular medications and she has never smoked. Apart from mild tenderness over both l...

Cutaneous pigmentation results from the synthesis of melanin by the melanocytes. Its distribution pattern in the surrounding keratinocytes determines the actual colour of the skin. ACTH and α-MSH are equipotent at the melanocortin-1 receptor (MC-1R) that is expressed on the cell surface of melanocytes. Activation of these receptors stimulates both proliferation of melanocytes and melanin synthesis.We present the case of a 66-year-old lady. Originall...

Osteomalacia is most commonly caused by vitamin D deficiency. This typically results in features of secondary hyperparathyroidism and hypophosphataemia. PTH secretion is however dependant on normal serum magnesium levels. Hypomagnesaemia due to malabsorption, diuretic or laxative abuse may lead to functional hypoparathyroidism despite typical features of osteomalacia.A 24-year old Afro-Caribbean woman presented with bilateral knee and upper back pain wit...

Obesity is accompanied by chronic diseases including cardiometabolic diseases. Obesity is also an independent factor of renal risk that deserves to be taken into account. The aims of our work were to determine the prevalence of chronic kidney disease related to obesity independently of all other usual risk factors and to describe its epidemiological characteristics in our population. We conducted a prospective descriptive and analytic study over a period of 12 months in 38 pat...