Endocrine Abstracts

A 58-year-old previously fit and well man presented with sudden onset severe epigastric pain associated with frequent episodes of vomiting. The pain was constant and relieved only with morphine. He was febrile otherwise systemic examination was normal. Serum sodium 132 mmol/l and serum potassium 4.4 mmol/l. The rest of blood testes including; full blood count, liver functions, glucose, amylase, corrected calcium, D-dimer, troponin, urea and creatinine were all normal. ECG, che...

Somatostatinomas are rare neuroendocrine tumors usually arising from the pancreas and duodenum. Symptoms include hyperglycemia, cholelithiasis, diarrhea and steatorrhoea. Treatment with somatostatin (SST) analogue may appear paradoxical, but can lower SST levels and improve symptoms.Case: A 60-year-old gentleman presented with diarrhoea, opening his bowels between 12 and 13 times a day causing him to stop working and become depressed. Repeated fasting gu...

Background: The National Institute of Clinical Excellence (NICE) published guidelines in May 2002 on the use of GH in children, recommending GH in 4 conditions: GH deficiency (GHD), Turner Syndrome, Prader-Willi Syndrome and chronic renal insufficiency.Aim: To audit whether GH prescribing at our hospital adheres to NICE guidelines.Methods: A retrospective audit was performed of children commenced on GH treatment between May 2002 an...

Background: CHF manifestations can be explained by the biologic effects of tumor necrosis factor-alpha (TNF-alpha). Interleukin-10 (IL-10) has potent deactivating properties and is considered a potent anti-inflammatory cytokine that inhibits TNF-alpha production. This study was designed to examine the role of IL-10 in patients with CHF and to test its correlation with pro-inflammatory markers.Methodology: Fifty patients with CHF were studied. Patients we...

Ritonavir is a protease inhibitor used in the treatment of HIV infection. It can potentiate the effect of inhaled corticosteroids, resulting in iatrogenic Cushing’s syndrome.We present a case of a 21-year-old female who had acquired HIV infection at birth, who also had moderately severe asthma since childhood treated with inhaled salbutamol 100 mcg prn and fluticasone 500 mcg bd. She had twice-yearly exacerbations requiring oral steroids. She commen...

The secondary sexual characteristics such as a neck mane and antlers seen in the male red deer are unusual in that they are produced on an annual basis and are linked to the breeding season. This cycle is highly controlled and the development of these characteristics coincides with changes in plasma levels of testosterone and IGF-1. We have previously shown that the expression of the androgen receptor in the hair follicle cells of the neck mane are only present during the bree...

Introduction: The uncontrolled diabetics are led to develop severe infections like severe forms of acute bacterial dermo-hypodermitis. The aim of our study was to clarify the epidemiological, clinical and therapeutic characteristics of BDH in diabetic patients.Patients and methods: A prospective, descriptive and analytical study was conducted in the Diabetology, Endocrinology and Metabolism Department, Ibn Rochd University Hospital of Casablanca, from Ja...

Introduction: The Flexible Insulin therapy (FIT) is considered as the therapeutic reference of type 1 Diabetes mellitus. FIT Improves diabetic patient’s quality of life with a great benefit, through food flexibility while providing optimal glycemic control with reduced incidence of both acute and chronic complications. The aim of the study was to evaluate satisfaction on changing treatment as a result of education FIT.Methods: Prospecti...

Introduction: Puberty is associated with various hormonal changes which can influence glycemic control in youth with type 1 diabetes mellitus, especially with the increase in growth hormone. Conversely, a poor control of diabetes can lead to delayed puberty.Objective: To assess pubertal status in young patients with diabetes Type 1 and determine factors that influence pubertal development.Patients and methods: Analytical retr...

Introduction: The thyroid emergency is a rare and life-threatening condition. These are severe complications of benign thyroid disease.Patients and method: We report cases of thyroid pathology constituting an emergency and have been collected over 2 years in the department of endocrinology of the CHU Mohammed VI of Marrakech.Results: Four cases of thyroid emergency were reported: three cases of acute thyrotoxic cri...