Endocrine Abstracts

Vitamin D is an essential hormone for skeletal metabolism across the lifecycle. Rickets and osteomalacia, uncommon manifestations of vitamin D deficiency in western countries, are still common in the Middle East and Asia (1, 2). Furthermore, low bone mass and fractures, latent manifestations of vitamin D insufficiency, are common conditions worldwide (3, 4). Serum 25-hydroxyvitamin D (25-OHD) level is the best index of vitamin D nutritional status, and whereas it is generally ...

Primary hyperparathyroidism (PHPT) is a common and for the most part an asymptomatic endocrine disorder, usually discovered by routine biochemical screening, in western populations; and increasingly now in other parts of the word. It is characterized by abnormal calcium-PTH dynamics, manifesting with mild hypercalcemia, with increased or inappropriately normal plasma parathyroid hormone (PTH) levels. PHPT is most commonly seen in older post-menopausal women. In countr...

IntroductionInsulin autoimmune syndrome (IAS), is rare cause of hyper-insulinemic hypoglycemia due to production of autoantibodies against the endogenous insulin in persons not formerly received insulin with no evidence of pancreatic lesions. Most described cases were in Asian peoples and this is the first case reported from Egypt.Case reportA 64-year-old Egyptian female presented with repeated postprandial h...

Introduction: Malignant pheochromocytomas present a real challenge for practitioners. This entity of tumors is rare, with complex characterization, and heterogenocity in their evolution and prognosis. Given the rarity of this tumor group, there is no consensus on the therapeutic management. The management must be in a multidisciplinary framework. Through this illustrative case, we propose a literature review of this rare entity with discussion of the different therapeutic opti...

Introducing: Primary hyperparathyroidism (HPT1) is a frequent endocrinopathy. Diagnosed incidentally or in front of a urinary or bone symptomatology, we report a case of primary hyperparathyroidism in the mode of revelation makes the originality “a paralyzing sciatica”.Observation: The patient was 44 years old and was undergoing neurosurgery for chronic low back pain that was resistant to etiological treatment. In view of the persistent and hyp...

Introduction: The HAIR-AN syndrome, which consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN), is an underdiagnosed endocrinopathy.Observation: We report the case of Miss A.M., 24 years old, admitted for exploration of hyperandrogenism. Anamnesis: the patient reported polyuropolydipsic syndrome and the notion of weight gain without eating disorders, making a total of 28 kg in 6 months. This period is also marked by th...

Introduction: Kallmann syndrome (KS) is a rare disorder. It is now designated as olfactogenital dysplasia with an association between agenesis of the olfactory bulbs and hypogonadism. The association of KS with a pituitary microadenoma has not been well described in the literature.Case report: It’s a 16-year-old and 6 months, admitted for evaluation of a micropenis, he has as ATCDs an orchidopexy performed at the age of 3 years, infertility in the m...

Introduction: Amiodarone is an anti-arrhythmic drug rich in iodine compounds. One 200 mg tablet corresponds to about 25 times the daily requirement of iodine. One of the major complications of taking Amiodarone is the development of dysthyroidism which is observed in 15% to 20% of cases. Hyperthyroidism occurs in 1 and 13% of these patients.Case report: We report the case of an 34 year old female patient, followed for complete arrhythmia by atrial fibril...

We present a case of a 56-year-old male who reported to us with history of instability of gait since one year which was acute in onset and progressive, there was also history of hearing impairment and constipation since 3 years without improvement despite several symptomatic treatments. There was no history of weakness in any part of body, headache, vomiting, convulsions or alteration of sensorium. There was no history of trauma to the head, fever or drug intake. On examinatio...

Systemic lupus erythematosus is a serious autoimmune disease characterised by the production of antinuclear antibodies directed particularly against native DNA. Its presence increases the susceptibility to develop other autoimmune diseases including autoimmune dysthyroidism. We present the case of a patient who presented with profound hypothyroidism as part of the work-up for lupus nephropathy. Female patient, 40 years old, reports physical asthenia for 2 months. On clinical e...