Endocrine Abstracts

Introducing: Hypothyroidism is the most common endocrinopathy causing rhabdomyolysis. Muscle manifestations are common in hypothyroidism, but myopathy is most often limited to discrete clinical signs such as myalgias, stiffness or cramps accompanied by a simple elevation of muscle enzymes. On the other hand, rhabdomyolysis associated with hypothyroidism is a rare diagnosis to our knowledge. We report a case of severe rhabdomyolysis in the setting of profound Hashimoto’s h...

Graves’ disease is a rare and severe disease that most often affects older children and is predominantly female. The diagnosis is made in the presence of a clinical picture very suggestive of thyrotoxicosis, confirmed by biological and radiological tests. We present the case of an 11-year-old female patient who presented with a moderate presented of basedow with an ultrasound appearance of thyroiditis for which scintigraphy was helpful in the diagnosis. Female patient, 11...

Introduction: Hypothyroidism is the most common endocrine dysfunction during pregnancy. In pregnancy, hypothyroidism is most often due to chronic autoimmune thyroiditis (Hashimoto’s disease) The consequences of hypothyroidism vary depending on the time of onset of hypothyroidism during pregnancy and the etiology retroplacental hematoma is a serious complication of hypothyroidism We report the case of a patient with in utero fetal death on retroplacental hematoma complicat...

Introduction: The association of multi-organ autoimmune disorders is described. We report a case of Hashimoto’s thyroiditis (HT) and primary biliary cholangitis (PBC), both are a chronic autoimmune inflammation, with lymphocytic infiltration and destruction of thyroid cells for (HT) and progressive destruction of intrahepatic bile ducts leading to cirrhosis for (PBC)Case report: 54-year-old female patient, followed for (PBC) at cirrhosis stage admit...

Introduction: Liver function abnormalities in hyperthyroidism are common, several abnormalities have been reported: hepatic cytolysis, cholestasis, insufficiency or even non-specific abnormalities. The pathophysiology of hepatic dysfunction secondary to hyperthyroidism is not yet well established. Graves’ disease can be associated with various autoimmune diseases. However, association with Primary biliary cirrhosis has been described in few cases in literature. We report ...

Introduction: Pheochromocytomas are catecholamine producing tumors which arise from chromaffin cells within the adrenal medulla. Silent pheochromocytomas are rare entities that do not present with the classical symptoms commonly seen in catecholamine-secreting tumors. Case report: We report a case of 70-year-old-woman patient who presented with left sided abdominal pain and discomfort for 6 months. A preoperative Computed tomography (CT) scan showed a hu...

Introduction: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors that are usually benign, but which may also present as or develop into a malignancy. Predicting such behavior is notoriously difficult and there are currently no curative treatments for malignant tumors.Case Report: A male patient aged 23 years old who was investigated for headaches, flushing and palpitations. The patient presented with classic clinical features of NF-...

Introduction: Mild autonomous cortisol secretion (MACS) is a term used to describe biochemical evidence of abnormal cortisol secretion in patients with adrenocortical adenomas (ACA), but without the classical external manifestations of overt Cushing’s syndrome (CS).Materials and Methods: In this study, we report a case of patient who presents mild autonomous cortisol secretion among incidentally discovered adrenal masses; followed in unit of the end...

Introduction: The prevalence of megaloblastic anemia in the adult population is poorly documented, but in the elderly, it has been clearly shown that the prevalence of macrocytic anemia increases after the age of 65 years especially in men. The most frequent etiology of vitamin B12 and folate deficiency is malabsorption. They have an action in the conversion of homocysteine to methionine: an increase in homocysteinaemia is currently considered a cardiovascular risk factor. Str...

Background: A 17 alpha-hydroxylase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia (CAH). Congenital adrenal hyperplasia (CAH) is a group of disorders resulting from defect of one of enzymes necessary for biosynthesis of cortisol.Case Report: A 33-year-old female suffered from 17OHD. She presented with primary amenorrhea, lack of secondary sexual characteristics, and hypertension complicated by ruptured cerebral aneurysm. Laboratory t...