Endocrine Abstracts

Introduction: Diabetic osteoarthropathy (D.O) commonly referred to as Charcot’s foot is a complication secondary to neuropathic and inflammatory osteolysis, occurring in a setting of old and/or poorly controlled diabetes. Its pathophysiology remains poorly understood and its diagnosis must be systematically evoked in the presence of any inflammatory sign that localised to the foot or ankle occurring on a background of diabetic neuropathy.Clinical ca...

Introduction: Centropontic myelinolysis (CPM) is a neurological pathology related to axonal demyelination lesions, often localized at the pontine level. For a long time, this condition was attributed to rapid correction of hyponatremia. A few cases of PCM with normal natraemia have been described, in a context of undernutrition, chronic alcoholism, hypokalaemia or hyperglycaemia.Patient and observation: We report the case of an 18 years old patient, type...

Introduction: Human immunodeficiency virus (HIV) infection and certain antiretroviral (ARV) treatments are associated with an increased risk of developing certain chronic comorbidities including type 2 diabetes, which is more prevalent in HIV-infected individuals. The coexistence of diabetes and HIV infection makes the standard of care more complex. The objective of this work is to discuss the relationship between these two comorbidities and to update physicians on the diagnos...

Introduction: Sinonasal neuroendocrine carcinoma SNECs are a rare group of neoplasms that account for only 5% of all sinonasal malignancies. SNECs are categorized by their differentiation grade into well-, moderately- and poorly differentiated.Case report: We describe a classical case of SNEC with secondary orbital involvement in a 34-year-old male patient presented of the occurrence of a right epistaxis. First of all, the patient is smoking. The beginni...

Introduction: Malignant tumors, nevertheless, have been associated with extremely high circulating ACTH and cortisol levels, and short duration of symptoms of Cushing syndrome (CS) besides atypical clinical phenotype, when compared with pituitary-dependent Cushing. Identification of the source of ACTH can be challenging, as sometimes the primary lesion is not identified even after prolonged and repeated follow-upCase report: A 33-year-old woman with a hi...

Introduction: Familial neurohypophysial diabetes insipidus (FNDI), an autosomal dominant disorder, comes in many forms that are differentiated by the inheritance pattern and the underlying genetic lesion. The disease is caused by mutations in the vasopressin-neurophysin 2-copeptin protein (AVP-NPII), in wolframin (WFS1) or in proprotein convertase subtilisin/kexin type 1 (PCSK1) genes.Materials and methods: In this study, we report a case of familial neu...

Introduction: Carotid body tumor is a hypervascular tumor with multiple feeding arteries and unique orientation at the carotid bifurcation. Although resection is a radical therapy for this tumor, complete resection is challenging.Case report: A 33-year-old female patient consulted with a neck swelling that had persisted for 3 years. On physical examination, a movable and pulsating hard mass was found on the left side of her neck. Computed tomography, mag...

Introduction: Intermittent Cushing’s syndrome is characterized by alternating episodes of hypercorticism with periods of eucorticism. It is a rare but well-defined entity and should be known. It remains a diagnostic challenge sometimes particularly difficult in endocrinology, we report a case.Case presentation: A 22-year-old diabetic patient on metformin, who consulted us because of a weight gain with the appearance of stretch marks for 2 months. Th...

Introduction: Cushing disease is the most common cause of endogenous hypercortisolism. Pituitary surgery is the first-line treatment and bilateral adrenalectomy is the option of last resort due to its severe consequences.Observation: This is a 24-year-old patient followed for cushing disease revealed by a severe cushing syndrome, a urinary cortisol at 20 times normal and negative dexamethasone suppression test with a pituitary microadenoma on MRI. He was...

Introduction: Pituitary apoplexy is a serious medical complication of a pre-existing pituitary adenoma characterized by a variety of clinical symptoms ranging from mild headache to neurologically impaired and finally comatose patients.Case report : We report a case of apoplexy in a large prolactinoma resulting in empty sella syndrome with a successful pregnancy. Our patient is a 31-year-old female, with a history of macroprolactinoma for approximately 7y...