Endocrine Abstracts

Studies showed an increase of cardiovascular risk (CVR) and reduction of the life expectancy observed in the anterior pituitary insufficiency (API) subjects. The morbimortality would be related to GH deficiency not substituted.Aim: To seek the frequency of the hypertension and analyse the predictive factors in subjects with API.A retrospective study relating 55 (47 women, eight men) subjects with API: interrupted pituitarystalk n:6...

Introduction: Testosterone therapy for hypogonadal men has been used for decades. However, there are still concerns regarding the safety of this treatment, particularly in elderly men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 66 months.<p class="abst...

The aims of the study were to analyze the relationship among insulin resistance, obesity, dysglycemia, dyslipidemia and to evaluate the role of common variants in candidate genes for their ability to predict the metabolic syndrome and cardio-metabolic risk factors.Subjects and methods: 752 non-diabetic individuals (190 males and 562 females; age 35.05+4.47 years, BMI 26.72+5.92 kg/m2) participating in the study were genotyped for variants in p...

Introduction: Obesity is associated with reduced testosterone, and low testosterone induces weight gain. This study analysed the effects of normalization of serum testosterone in mainly elderly, hypogonadal men.Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤ 3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 6...

We report a case of Cushing’s disease associated to nephrotic syndrome. A 21-year old female was admitted to Cittadella-Hospital due to recent occurrence of weight gain, acne, hirsutism, amenorrhea and mild hypertension. Physical examination revealed truncal obesity, moon face, buffalo hump and a bilateral ankle edema. Suspected hypercortisolism was confirmed by elevated 24 h urinary cortisol (385 μg/24 h, normal range 32–250 μg/24 h) and failure to suppres...

A 22-year old female diagnosed with thyrotoxicosis with raised free thryroxine (16.8 pmol/l) and suppressed thyroid-stimulating-hormone (TSH<0.03 mIU/l). She was started on Carbimazole 20 mg during end of August 2011. A fortnight later she presented with nausea, vomiting, fever and rigors. Her renal functions were deranged with a creatinine of 704 μmol/l, which worsened over the next 48 h. She subsequently needed renal replacement therapy with haemodialysis. She was c...

Introduction: Thyroxine is essential for growth and brain development in neonates. Early detection of hypothyroidism by measurement of free T4 (fT4) is therefore paramount. Moreover, the initial monitoring of Thyrax suppletion requires accurate fT4 measurements.Methods: In the Maasstad Hospital fT4 has been measured with the Immulite 2500 and from 2010 onward with the Dimension VISTA. Both instruments show good...

Subtotal parathyroidectomy (SPX) and total parathyroidectomy with autotransplantion (TPXAT) are adequate techniques in treatment of secondary hyperparathyroidism (HPT2) in hemodialysed patients with identical results. Reinterventions required for persistence or recurrence of HPT2 may seem easy after TPXAT: no redo-surgery in the cervical area and removal of grafts in the forearm under local anaesthesia. The aim of this study was to analyze our results of reiterative surgery in...

The GH/IGF axis has been implicated in the pathogenesis of retinopathy in diabetic subjects, the aim of this study is to evaluate the prevalence of diabetic retinopathy in hypersomatotropic patients.Subjects and methods: Twenty four hypersomatotropic patients (12 females, 12 males mean age =49 years, mean hypersomatotropic duration =11 years) have diabetes for 7.25 years in average. To search for diabetic retinopathy a funduscopy was performed in all pat...

The effects of goitrogens on the thyroid gland have been much studied and calcium is considered as a goitrogen in some cases. Since the level of calcium is high in drinking water of some cities of Khuzestan province, the effects of high calcium intake on the function of thyroid gland is investigated in this study. For this purpose the concentration of thyroid hormones is measured in rats.The study was carried out on73 male and female rats. The animals we...