Endocrine Abstracts

The first patient with a catecholamine-secreting paraganglioma that was sucessfully resected was in 1926. Over the past 97 years, there has been a dramatic evolution in the clinical presentation, methods used to diagnose and localize, and germline genetic testing of paragangliomas (PGLs). When contrasted to adrenal pheochromocytoma, PGLs present the clinician with unique challenges, which include: 1) diverse location—they may be located anywhere from the tympanic membrane...

Both genetic and environmental factors determine whether individuals who have a predisposition to the development of type 1 diabetes actually develop the disease. Although we now know a considerable amount about the genetics through genome wide scans, and diabetes risk scores have been developed, the actual environmental triggers or perpetuating factors are not clearly defined. There has been considerable interest in recent years in investigation of these possible environmenta...

This practical and interactive session will explore the difficult clinical presentation of sweating.This problem is very commonly encountered in primary care, and can present a major diagnostic and management challenge. In practise, although there are multiple endocrine causes for excessive sweating, in the majority of cases presenting with this symptom alone, no endocrine cause is found.An overview of the most important aspects of...

Hirsutism is the presence of excessive terminal hair in androgen dependent areas of the female body. A frequent medical complaint that affects ∼ 12% of Caucasian premenopausal women, hirsutism usually results from relatively benign functional disorders. Among them, the polycystic ovary syndrome is the most frequent etiology.The most important tool for the diagnosis of hirsutism is a complete clinical history and physical examination. Functional cau...

Previously asymptomatic 29-year-old Saudi male patient, presented to with a history of dizziness, abdominal pain and diarrhea for three days.His morning 800 h serum cortisol was 6.4 μg/dl (normal: 5–25 μg/dl); plasma ACTH was 7579 pg/ml (normal: <46.00). The diagnosis of acute adrenal crisis was made which confirmed later by a defective rise in the cortisol level with ACTH stimulation test.The patient was admitte...

Vitamin D deficiency has a leading role in endothelial functions and pathogenesis of type two diabetes and is supposed to take part in atherosclerosis. In this study we aimed to investigate the correlation between markers of atherosclerosis and inflammation with 25(OH)D levels in patients with type two diabetes. Forty patients with type two diabetes and macrovascular complication and 40 patients without macrovascular complication were included in the study. Thirty healthy subj...

Struma Ovarii and its malignant transformation to thyroid-type carcinoma are rare conditions. In recent reviews of reported literatures, only 53 cases of papillary thyroid-type carcinoma arising from struma ovarii were documented from 1924 to 2008. Due to the rarity of the disease, lack of uniform histological criteria for malignancy and protracted clinical course, its management is not also universally accepted by physicians. The aim of this paper is to present a very rare ca...

Accurate and sensitive detection of the biomarkers is important both for preclinical research fields such as biochemistry, biomedicine, and clinical diagnostics. Immunosensors are the miniaturized analytical devices that combine high specificity of immunological reaction with sensitivity of detection techniques.In this study, we developed a new competitive immunosensor with employing antibody (Ab) labeled AuNP (Ab-AuNP) and mobile crystalline material-41...

The goal of this study was to determine whether galanin increase aromataze gene expressions and estradiol 17-β concentrations in ventromedial (VMH) and lateral hypothalamic area (LH). Forty rats were randomly divided into four groups. Animals in different groups were received either saline, 1, 2 or 4 ng galanin into their VMH and LH. After infusion of galanin, VMH and LH tissue were separated and homogenized. Homogenized sample were assayed for aromataze gene expression b...

Background: Testosterone substitution with favourable kinetics and tolerance is important for hypogonadal men. Intramuscular injections of long-acting testosterone undecanoate (TU) offer a convenient modality.Methods: We report data from 281 patients (134 with primary, 88 with secondary hypogonadism and 59 with late-onset (‘mixed’ or ‘metabolic’) hypogonadism aged 15 to 72 years (mean 40±13 years) receiving altogether 4913 intram...