Endocrine Abstracts

The neuroendocrine cascade regulating episodic growth hormone (GH) secretion plays a central role in post-natal growth and metabolism. Intermingling of GH cells with other pituitary cell types and the complex distribution of the hypothalamic GHRH neurons makes both the cell types difficult targets for selective physical or chemical manipulation. On the other hand, they are excellent targets for physiological transgenesis since their major secretory products derive from highly ...

Iain CAF Robinson, National Institute for Medical Research, Mill Hill, London, UK AbstractIain Robinson was born in 1949 and educated at the King Edward VII Grammar School in Sheffield before going to Worcester College, Oxford, to study physiology and medicine. Awarded first class honours in physiology and with medical studies deferred, Iain received an MRC studentship Award for studies on endocrine physiology in the D...

The identification of leptin as a gene product produced in fat revitalised interest in the means by which the brain receives signals to regulate appetite, energy expenditure and the neuroendocrine system. We have studied the effects of alterations in bodyweight on the expression of appetite regulating peptides in the brain and have also determined effects of leptin on a range of parameters in the hypothalamus and pituitary gland of the ovariectomised female sheep. Intracerebro...

Iain Clarke, Prince Henry's Institute of Medical Research, Clayton, Australia AbstractDr Clarke is a leading researcher in the field of neuroendocrinology. In the early 1980s he and Mr James Cummins (a neurosurgeon at St Vincent's Hospital) developed methodology to enable the collection of blood from the hypophseal portal system. This permitted the first ever measurements of real-life secretions of brain hormones unde...

Introduction: The association of multiple myeloma (MM) with primary hyperparathyroidism (pHPT) is very infrequent. In addition pHPT may be overlooked or later diagnosed, because on the one hand certain clinical and laboratory characteristics of MM, such as hypercalcaemia, asthenia, osteoporosis and impaired renal function overlap with the elements of pHPT, on the other hand modern pHPT include non-classical (e.g. normocalcemic or mild clinical) forms. We present the case of a ...

Objective: To evaluate the effect of selenium on autoimmune thyroid diseases through ATPO-titers.Material and methods: Selenium (0.1–0.2 mg/day) was associated to basic treatment of thyroid dysfunctions in 21 female patients with high ATPO-levels (normal<34 U/ml). We followed the thyroid function and ATPO-values usually after 2–6 months of selenium administration.Results: Ten hypo-thyroid patients had Hashimoto’s...

Background: Primary hyperparathyroidism (PHPT) is often only mildly sympthomatic1. Nevertheless, some patients are diagnosed late and severe complications such as osteitis fibrosa cystica can develop.Case Presentation: A 32 years old female was hospitalized due to pain in the left femoral region after falling from standing height. Radiological investigations revealed left femoral pathologic fracture and bone malignancy was suspected. Further r...

Congenital hypopituitarism is a rare disease, occurring sporadically in the vast majority of cases, that is found more frequently in males. We are presenting the case of a 19 year old that addressed our clinic because of short stature and lack of development of secondary sexual traits. During the clinical assessment we found his height to be 146 cm, corresponding to -4.78 SDs, Tanner stage of pubertal development 1 and lack of apocrine axillary odor. The patient was inapetent ...

Prolactinomas are the most common secreting pituitary tumors. Although most respond well to dopamine agonists, some prolactinomas are dopamine-resistant and very aggressive. Here we present a 37-year-old patient with aggressive prolactinoma.Case report: The 37-year-old patient was referred to the University Hospital Centre Zagreb in March 2020 for bilateral visual field defects and headaches due to prolactinoma. In 2017, he had a transsphenoidal resectio...

Background: Turner’s syndrome is the most common sex chromosome abnormality in females resulting from a 45,X cell line. A mosaic chromosomal complement (e.g. 45,X/46,XX) is detectable in over half of all patients with Turner’s. Characteristically girls with Turner syndrome have a short stature attributable to the presence of SHOX (short stature homeobox-containing gene on the X chromosome) gene. Most affected women have no pubertal development and primary am...