Endocrine Abstracts

Anti-Müllerian hormone (AMH, Müllerian inhibiting substance) is a protein hormone expressed by the Sertoli cells of the testes and the granulosa cells of the ovaries. AMH is best known for its paracrine functions in reproductive organ development and function. The hormonal roles of AMH are largely unexplored, but functions are emerging in growth and brain development. To date, there is no putative function for AMH in the blood of adults. AMH belongs to the TGF-β...

Introduction: Adipose tissue is a source of peptides with paracrine and endocrine actions, called adipokines. Adipokines produced by periadventitial fat have been implicated in vascular pathology, including atherosclerosis. We investigated the expression of novel adipokines chemerin and vaspin, as well as visfatin, apelin and adiponectin in human pericoronary and periaortic fat in correlation with coronary and aortic atherosclerosis.Methods: Paraffin emb...

Myeloperoxidase (MPO), an enzyme of the innate immune system, exhibits pro-atherogenic effects and includes influence on oxidative damage to LDL- and HDL-cholesterol, and promotion of endothelial dysfunction.The aim: To investigate the disturbance of MPO in type 2 diabetic (T2D) patients depending on intensity of atherosclerosisMaterial and methods: We investigated 244 patients aged from 45 to 60 years (M±SD 54.0±4.63) in...

Introduction: Prolactinomas are rare in childhood and adolescence, representing a half of pituitary adenomas (1% of intracranial tumors); macroadenomas are more frequent than microadenomas. The signs and symptoms depend on age, sex, tumor size and prolactin level. Due to a higher frequency of macroadenomas in boys, they present more often neuro-ophthalmologic findings (impaired vision, headache)Case report: We present a case of 25-year-old pacient diagno...

Prolactinomas represent 60% of primary pituitary tumors, galactorrrhoea and menstrual disturbances beeing the most frequent clinical features in women. The mass effect of macroadenomas is expressed by headache, visual field defects and hypopituitarism. The aims of therapy are reduction of tumour size, prevention of tumour expansion and restoration of gonadal function. Dopamine agonists normalize prolactin secretion and reduce tumour size in 40% of patients with macroadenoma.</...

Introduction: Only few cases of true hermaphroditism with male phenotype and 46,XX/ 47,XXY Klinefelter’s mosaic karyotype with clinical features different among cases have been previously described.Case report: A 12-year-old patient was referred to our clinic for mixed gonadal dysgenesis. Since birth he has ambigous genitalia: unilateral criptorchidism on the right and perineal hypospadia; left gonad was palpable in the scrotum since birth. At the a...

Introduction: Co-existence of medullary thyroid carcinoma and primary hyperparathyroidism (PHPT) is well described, however, the association of non-medullary cancer and PHPT is less recognised. Herein, we report two cases of patients with PHPT and papillary thyroid carcinoma (PTC).Case 1: A 55-year-old woman received a diagnosis of PHPT during investigation of her anemia. (Ca: 11.4 mEq/l, PTH: 256 pg/ml, urinary calcium: 960 mg/day). Thyroid function tes...

Introduction: Endocrinologic dysfunction is a well-known complication after hematopoietic stem cell transplantation (HSCT) in children. The mechanisms of thyroid damage developing after transplantation remain not completely recognized. Toxicity of the conditioning regimen, especially total body irradiation, is most commonly postulated cause of endocrine abnormalities; immunological mechanisms (e.g. graft vs host disease) may also contribute to thyroid dysfunction.<p class=...

Introduction: Deranged mitochondrial biogenesis has been linked to obesity with or without type 2 diabetes but this association has not been reported in non obese type 2 diabetes subjects. This study attempts to identify the various alterations of mitochondrial biogenesis in adipose tissue in obese and non obese type 2 diabetes subjects.Methods & Design: Since type 2 diabetes is associated with elevated serum leptin and depressed serum adiponectin le...

Introduction: Deranged Mitochondrial bioenergetics is a key feature of type 2 diabetes and obesity but its status in non-obese type 2 diabetes patients is not known. The aim of the present study was to assess the status of mitochondrial oxidative phosphorylation and ROS metabolism in subcutaneous adipose tissue isolated from 4 groups of subjects: non-obese subjects with type 2 diabetes (NOT2D), non-obese non diabetic (C), obese non-diabetic (OB) and obese type 2 diabetes subje...