Endocrine Abstracts

Introduction: Clinical practice guidelines on diabetes mellitus (DM) was created by The Society of Endocrinology & Metabolism, Turkey (SEMT). The ADMIRE Project is designed to evaluate the effect of implementation activities to increase physicians’ awareness on guidelines.Methods: A total of 180 physicians from national representative diabetes clinics kept medical records of 885 T2DM patients for 6 months, without any interference to their routi...

Aim: We have proposed to study the modulation of the Notch pathway in diabetes having in mind the essential role played by the Notch system in the regulation of cell differentiation and angiogenesis.Methods: The effect of hyperglycemia on Notch system was studied in vitro and in vivo using western blot, reporter gene assay or evaluation of target genes (qRT-PCR). The functional consequences of the Notch system modulation were studied by the...

Introduction: The prevalence of diabetes mellitus among Nigerian adults has been increasing over time. A considerable number of chronic complications of DM can be adequately prevented, however, the proportion of patients presenting with chronic complications of DM in our setting is still relatively high.Objectives: This study was carried out to assess the pattern of chronic diabetic complications among patients attending the diabetic clinic of Lagos Univ...

Introduction: An update of health economics analysis of diabetes mellitus (DM) in Turkey was performed. The primary objective was to collect and calculate the healthcare resources utilized for the management of DM.Methods: Thirty-one out of 40 randomly chosen centers completed the study. Medical files were reviewed for the data recorded for at least two years prior to the study. Collected data included laboratory tests, treatments, inpatient/outpatient f...

The aim was to evaluate the space of hyperhomocysteinemia presence with depression and diabetic nephropathy (DN) in diabetic mellitus type 1 (DMT1) patients.Materials and methods: it was examined 147 patients with DMT1 (57.1% of males, 42.9% - females) and duration of disease was 11.17 [9.07;12.26] years. Moderate age was 40.08 [30.44; 48.79] years. DN of 3–5 stages was diagnosed in 43 patients (29.3%). To provide analysis it used blood serum creati...

Introduction: The recent ADA and EASD algorithm for the treatment of type 2 DM suggests addition of basal insulin or GLP-1 agonist to pre-existing treatment when glycemic control is not achieved.Aim: Compare efficacy and safety of exenatide (E) versus insulin Glargine (G) added after metformin monotherapy.Patients and methodOur study was open labeled, non- randomized, retrospective and included 48 patients, 1...

A 66-year-old woman had no history of systemic diseases. She had developed watery diarrhea for 4 months initially, without abdominal pain, fever, any aggravating or relieving factor. She visited gastroenterologist, and colonoscopy showed only mixed hemorrhoid. Irritable bowel syndrome was impressed then. Thus, anti-spasmodics and anti-diarrheals were prescribed. However, diarrhea persisted for 1 year, and body weight loss of 7 kg occurred during this period of time. She later ...

Introduction: Pheochromocytomas are rare but treacherous catecholamine-producing tumors of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue. We refer a case with stabilization of tumor growth and hormonal improvements following repeated s.c. injections of octreotide.Case report: We report a female patient aged 35 with a finding of bilateral adrenal mass with sever cardiovascular symptomatology (f...

The patients with polycystic ovary syndrome (PCOS) are at increased risk for insulin resistance, central obesity, dyslipidemia and hypertension. In our study, we aimed to detect whether women with PCOS who had normal OGTT results have had insulin resistance. Moreover we investigated the association of probable insulin resistance with cardiovascular risk indicators such as hs-CRP and carotid intima media thickness (CIMT).In total, 34 untreated PCOS patien...

Testosterone has a dose-dependent stimulatory effect on erythropoiesis but the mechanism is poorly understood. Although both erythroblasts and megakaryocytes express androgen receptors, testosterone’s effect on thrombopoiesis in humans has never been studied.We report a case of 53-years-old woman presented with androgenic alopecia, hirsutism, facial redness and hoarse voice. She was a non-smoker and had a history of well-controlled diabetes mellitus...