Endocrine Abstracts

The aim of the research was studying the influence of age and sex on the changes of bone mineral density detected on rats with experimental hyperthyroidism.Research object: Research is conducted on 180 white females and males rats of ‘Wistar’ breed. Animals were arranged in the 12 groups: six controls groups (CG) of pre-pubertal, reproductive and old males and females; six age-dependent groups of males and females rats getting L-...

The aim: To study age-dependent changes of bone mineral density of females and males rats in remote terms after hyperthyroidism abolition.Research Object: Research is conducted on 180 white females and males rats of ‘Wistar’ breed. Animals were arranged in the 18 groups: six controls groups (CG) of pre-pubertal, reproductive and old males and females; six groups of rats with the experimental model hyperthyroidism (HTG); six groups of rats 30 da...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It may result from various factors including erythropoietin (EPO) deficiency, iron and vitamin deficiencies, systemic inflammation, adverse effects of some drugs and others. However, the clinical significance of each factor is not fully known. The aim of this study was to assess the relative contribution of EPO deficiency, iron deficiency and systemic infla...

Incretin-based therapy can improve glucose control in type 2 diabetes (T2D) with no weight gain. Usually dipeptidyl peptidase-IV (DPP-IV) inhibitors considered as weight neutral and glucagon-like peptide-1 receptor agonists are associated with weight loss. Some trials showed non-remarkable weight-lowering effect on DPP-IV inhibitors. We aimed to identify patients on DPP-IV inhibitors which are likely to achieve both outcomes either good glycaemic control or weight loss.<p ...

Aim: – to study functional status of pituitary–gonads (PG) axis in males with obesity.Materials and methods: We evaluated 15 males with obesity without other associated pathology. Mean age of patients was 28.3 years old. Control group constituted by 20 healthy men with different age.All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile (LH, FSH, prolactin, ...

Few data on prevalence of thyroid diseases in neoplastic groups of patients has been reported. A slight increased prevalence of hypothyroidism and autoimmune thyroiditis in patients with breast cancer and cutaneous melanoma are been described.Aim: Of the study was to evaluate the prevalence of thyroid diseases in a group of non-endocrine neoplasm consecutively evaluated by the oncologist and endocrinologist in a iodine-sufficient area of north-east Italy...

Synopsis: Thyroid cancer with concomitant thyrotoxicosis is variably reported to be rare. Malignancy occurs as postoperative incidental finding of a small malignant focus in Graves’ disease, as part of a toxic multinodular or a toxic adenoma. We report two cases of large toxic multinodular goiters with metastasis diagnosed preoperatively as follicular neoplasm and confirmed postoperatively as differentiated thyroid cancer. Review of literature, pathophysiology and treatme...

Research objective: After the Chernobyl nuclear reactor accident, there was a dramatically increase in thyroid cancer incidence in children and adolescents in Belarus, Ukraine and the Russian Federation. The increasing incidence of thyroid cancer in last 10 years not only in former Soviet Union but also in the United States, is real medical problem. ‘Project Chernobyl’ has been established in New-York for early diagnostics of radio induced thyroid cancer among people...

Neuroendocrine tumor cells express a diverse array of activating and inhibitory receptors. Each receptor transduces a signal via individual pathways which often interact or overlap. Common stimulatory receptor families include those for EGF/TGFα, FGF, IGF, PDGF, VEGF, and TGFβ. EGF receptor (Her 1) activation results in several signal transduction cascades including Ras/Raf, MAPK, AKT and JNK leading to DNA synthesis and cell proliferation. Activated MAPK signaling i...

Background: Adolescence is a time of change and is associated with a deterioration in glycaemic control. Education is an important part of diabetes care and enables patients to understand how to manage their condition. An audit was carried out to assess whether adolescents with type 1 diabetes were being educated about social aspects of diabetes.Method: Fifteen adolescents between the ages of 13 and 17 were asked to subjectively score their knowledge of ...