Endocrine Abstracts

Objective: An adrenal incidentaloma is discovered in about 3–4% of patients undergoing radiological examination (CT/MRI) of the abdominal region. Current diagnostic algorithms for differentiating between benign and malignant lesions largely depend on imaging studies, which lack in specificity. This often leads to extended radiological follow-up of benign lesions, which is time-consuming, expensive and carries a health risk. It was recently suggested that urinary steroid p...

Objective: To evaluate the outcome of preoperative therapy with ketoconazole (KTZ) and/or metyrapone (MTP), in previously untreated CS patients who later underwent surgery.Design and methods: A total of 62 CS patients (85% ACTH-dependent), who have been treated with steroidogenesis inhibitors prior to surgery in our centre between 1983 and 2010, were retrospectively studied. T0 and t1 defined visit at baseline and at the end of medical treatment, respect...

It is well known that primary aldosteronism (PA) is frequently associated with metabolic syndrome. Among possible pathogenic mechanisms, adiponectine gene variants may play a role in the development of metabolic complications especially type two diabetes.Aim of this study was to assess the presence of two single nucleotide polymorphisms of the adiponectin gene (G276T and T45G) in patients with PA and determine their relation to metabolic parameters.<...

Objectives: We assessed the implications of PINP (procollagen type I N-terminal propeptide), NTX (cross-linked N-telopeptides of type I collagen), E2 (estradiol), calcium (Ca2+), phosphorus (PHOS(2−)), and their correlation with bone mineral density (BMD) in the process of bone remodeling of postmenopausal osteoporosis.Methods: The study was performed on two groups of women with postmenopausal osteoporosis (with different degr...

Aim: To assess the impact of education of people with T2DM and complications. Patients and methods. Observational study, 100 T2DM patients of age 35–75 years, both sex, duration of DM >1 year.Results. From 100 T2DM 47% were male sex and 53% female. Mean age 60.45±8y, duration of DM 10.45y±3 y. Average A1c 8%±0.6, BMI 27%, systolic BP 140±6 mmHg, TG 2.2±0.3 mmol/L, LDL 4.0±0.6 mmol/L. Education (diet, physical activities, drug compliance) ...

As for many tumor types, it has been shown that the Akt pathway is overexpressed and activated in human pituitary tumors. Thus, pituitary tumors may be sensitive to the anti-proliferative effects of mTOR inhibitors. However, part of non-functioning pituitary tumors are rapamycin-resistant. Torin1, second-generation ATP-competitive mTOR kinase inhibitor, suppresses both mTORC1 and mTORC2 complexes. To evaluate the in vitro effects of the mTOR inhibitor Torin1 on pituitar...

Background: Prolactin (PRL) hypersecretion is the most common endocrine abnormality due to hypothalamic-pytuitary disorders. Hyperprolactinemia occurs in 20–30% of cases with polycystic ovary syndrome (POS). It is considered that hyperprolactinemia is not involved in POS etiopathogeny, but other factors are implied.The aim of the study: was to retrospectively evaluate the diagnostic tools (Rotterdam criteria) and therapeuthic approach applied in 78 ...

Background: It has been reported that primary treatment with somatostatin analogues (SSA) is effective in up to 60% of acromegaly patients, but predictive value of the acute octreotide suppression test (OST) for selection of patients with good response to depot SSA in long term treatment remains controversial.Patients and methods: Twelve medical therapy naive patients (mean age 44 years, female 75%) with active acromegaly were included in prospective stu...

Introduction: During embryogenesis the descent of the thyroid may not proceed normally and may stop at various sites from the base of the tongue to any site of the thyroglossal duct.Ectopic thyroid tissue, defined as thyroid tissue not located at its normal site (anterolaterally to the second and fourth tracheal cartilages) is rare. Most often, ectopic tissue is located in the base of the tongue.Case report: We report a 75-year old...

Background: Sometimes, although the serum thyroid hormone levels are in desired ranges, the patient still has complaints. On the other hand, the dose of levothyroxine replacement may be variable in patients with hypothyroidism. These factors directly influencing the clinical practice may be, to some extent, associated with other immunological/allergic diseases that accompany autoimmune thyroid diseases (ATDs).Aim: To document the other autoimmune/allergi...