Endocrine Abstracts

Abstract unavailable....

Several observational cohort studies and one secondary prevention trial (the Lyon diet study) have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. The PREDIMED study is a multicenter, randomized, nutritional intervention trial designed to assess the effects of the Mediterranean diet (MedDiet) on incident cardiovascular diseases (CVDs), in the context of primary prevention of CVD. Participants (7447 elderly individuals at high r...

We present a commentary based on both history and experiences of the many contributions to steroid biochemistry and endocrinology made in Edinburgh over the past 75 years. Reflections will be made commencing with the contributions of Guy Marrian (1904–1981) and colleagues. Marian, occupied the Chair of Medicine with relation to Medicine (later Medical Biochemistry, then Biochemistry) at Edinburgh University from 1939 until his appointment as Director of the ICRF Laborator...

SARS-CoV-2 infection produces greater morbidity and mortality in people with cardiovascular disease, diabetes, and obesity, raising the possibility that the consequences of viral infection are modulated directly and indirectly by the endocrine system. Hospitalization and severity of illness is more common in males, further suggesting that sex, possibly male and female sex hormones, modifies the host response to coronavirus infection. SARS-Co-V-2 cellular infection requires ACE...

Abstract unavailable....

The angiotensin II type 1 receptor (AT1R) belongs to the family of seven trans-membrane (7TM) receptors, also referred to as G-protein coupled receptors. The AT1R is the primary effector of the renin–angiotensin system, and serves as a key regulator of cardiovascular physiology. The importance of the receptor is clearly illustrated be the frequent use of AT1R blockers and ACE inhibitors in cardiovascular medicine. Upon binding of Ang II th...

Metastatic thyroid cancer that are radioactive iodine-refractory (RAIR) have a high mortality, particularly if positive on [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET). We now have a better understanding of the genetic alterations implicated in the disease. Several studies along the last years have shown that constitutive activation of the mitogen-activated protein kinase (MAPK), triggered by rearrangements of RET and NTRK1 and activating mutations of RAS...

The LH receptor (LHR) together with the FSH receptor (FSHR) and TSH receptor (TSHR) constitute a highly conserved subgroup of G protein-coupled receptors. Activation of these receptors requires the binding of the glycoprotein hormones to the long and divergent N-terminus of the receptor and the intramolecular signal transduction from the hormone-receptor complex to the transmembrane domain of the receptor. The main signaling pathway of the LHR, TSHR and FSHR is stimulation of ...

Background: Hypovitaminosis D is associated with T2DM risk, cross-sectionally and prospectively; supplementation can reduce insulin resistance and increase glucose-induced insulin secretion in humans. Increased pancreatic islet RAS activity is induced by hyperglycemia, enhancing β cell damage (Leung PS et al.). Vitamin D is now known to suppress renin secretion, thus we have examined effects of calcitriol on increased islet RAS activity in vitro±hyp...

Adamantinomatous craniopharyngioma (ACP) is an epithelial intracranial lesion arising from Rathke’s pouch with a median age at diagnosis of 8 years. ACP is the third most common paediatric brain tumour, accounting for approximately 5–13% of brain tumours, and the commonest pituitary tumour among children. Although histologically benign, ACP often behaves aggressively with invasion of the hypothalamus and visual pathways. Consequences associated with both the tumour a...