Endocrine Abstracts

Introduction: Bartter syndrome represents a set of closely related autosomal recessive renal tubular disorders characterised by hypokalemia, hypochloremia, metabolic alkalosis and hyperreninemia with normal blood pressure. The underlying abnormality results in excessive urinary losses of sodium, chloride and potassium. Bartter syndrome is classified into 3 main clinical variants: neonatal Bartter syndrome, classic syndrome and Gitelman syndrome.Case repo...

Background: Low and high birth weight (BW) has been linked to the increased risk of infant mortality, obesity, diabetes, and cardiovascular diseases. Metabolic biomarkers, glucose, lipids and insulin in human umbilical cord blood could potentially reflect the new-born metabolic status. This study aims to assess the concentration of glucose, lipids and insulin in cord blood, and to investigate the association between these metabolic parameters and BW.Meth...

BackgroundMedullary thyroid carcinoma (MTC) accounts for 3–5% of thyroid cancers, but recurrent MTC, manifested by elevated calcitonin levels, is a common problem. We aimed to perform a calcitonin washout procedure simultaneously with cytological evaluation and compare their effectiveness to diagnose metastatic lymph nodes.Methods94 patients diagnosed with MTC were recruited from our institutional datab...

IntroductionIn Klinefelter syndrome, hypergonadotropic hypogonadism is the most prominent endocrine-metabolic disorder. However, a higher prevalence of cardiovascular risk factors has also been reported.ObjectivesIn a sample of individuals with Klinefelter Syndrome (KS): – to document the diagnostic context; – to assess the prevalence of cardiovascular risk factors (CVRF) and compare it with a contr...

BackgroundAlthough rare, hypoglycaemia in patients without history of diabetes should be recognized and studied, in order to reduce associated morbidity. Cotrimoxazole (TMP/SMX) is commonly used in clinical practice and hypoglycaemia is a rare side effect associated with its use. Literature advocates that this effect is due to the fact that SMX has the same sulphanilamide structural group of sulfonylurea, mimicking the hypoglycaemic effect by stimulating...

IntroductionNoonan syndrome can result from different mutations, the most frequent being in PTPN11. The diagnosis is often made by the clinical picture of short stature, facial dysmorphisms and heart defects. From an endocrine point of view, growth retardation, hypogonadism and a higher frequency of thyroid autoimmunity are highlighted.ObjectivesTo analyse endocrine features in patients with Noonan syndrome (...

IntroductionThere are very limited number of clinical studies and data on the effect of thyroid dysfunction in hypothyroidism on connective tissue. Tendinitis can be the first complaint in hypothyroidism and symptomatic relief can be provided with the appropriate treatment of primary thyroid deficiency. There are studies, showed softening in Achilles tendon with age, in patients with intermittent claudication, diabetes patients, and chronic kidney failur...

Objectives: Thyroid eye disease (TED) is considered a fibroinflammatory disease with pathology related to both inflammatory and fibrotic disease processes. IL-11 is a fibroinflammatory cytokine that is linked to tissue fibrosis of the lung, skin, heart, kidney and liver. Recently, IL-11 was identified as a possible disease modifier in TED. IL-11 levels are increased in TED patient plasma, in correlation with disease severity, and IL-11 stimulates phenotypic switching of orbita...

Purpose : To assess the utility of (18F)fluoroethyl-L-tyrosine PET co-registered with magnetic resonance imaging (FET-PET/MRICR) in patients with difficult-to-localize prolactinoma to inform clinical decision making and treatment planning.Methods: Retrospective cohort study of 17 consecutive patients with difficult-to-localize prolactinoma undergoing FET-PET/MRICR between October 2020 and Amgust 2022 for either (1) additional inform...

Objective: At present, there are no studies in which authors report the use of cardiac magnetic resonance imaging (CMR) to evaluate the differences in myocardial strain between patients with aldosterone-producing adenomas (APAs) and those with idiopathic hyperaldosteronism (IHA) or the improvement in myocardial strain after treatment.Methods: In this study, 71 patients with APA and 51 patients with IHA were prospectively enrolled from the Department of E...