Endocrine Abstracts

Background: Subacute thyroiditis (SAT) is a transient thyrotoxic state characterized by suppressed TSH and low uptake of iodine 123 on thyroid scanning. SAT is a self limiting, possibly viral and inflammatory thyroid disorder that is usually associated with thyroid pain and systemic symptoms. Many factors can cause SAT. Infections are considered the most common cause. Vaccines can also lead to SAT.Case report: A 46-year-old male with a history of type 1 ...

PTTG1-binding factor (PBF) is an oestrogen-regulated proto-oncogene that is overexpressed in thyroid, breast and pituitary tumours. The precise role of PBF in tumourigenesis, however, has not been established, nor whether it is also an aetiological factor in non-endocrine cancer. In this study, we investigated PBF function in established colorectal cells and human tumours. Specific binding was evident between the tumour suppressor p53 and both endogenous and exogenous PBF in H...

Thyroid cancer is the most prevalent cancer among endocrine malignancies. Surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers. However, regarding metastatic poorly differentiated or anaplastic thyroid cancers, there have been no available effective treatment modalities. The genomic instability, such as chromosome aneupolidy, represents a hallmark of s...

Objective: Acylation Simulating Protein (ASP) has been shown to regulate lipid clearance and glucose uptake in adipose tissue. In vitro studies demonstrate that insulin stimulates ASP secretion from adipocytes. Individuals with obesity and/or metabolic disturbances (insulin resistance and type 2 diabetes) have increased plasma ASP, suggesting ASP resistance. Therefore, the present study evaluates whether ASP levels are influenced by the metabolic profile of overweight and obes...

Hypothyroidism causes delayed ossification and growth retardation. T3 stimulates hypertrophic chondrocyte differentiation whereas unliganded T3 receptors (TRs) repress gene expression and maintain cell proliferation in the absence of hormone. During development the type 3 deiodinase enzyme (D3) inactivates thyroid hormones and prevents T3-access to the fetus. At birth diminishing D3 activity and increasing T3 availability triggers the onset of cell differentiation and correlat...

Background: Metastatic pheochromocytomas and paragangliomas are orphan neuroendocrine tumors. 50% of these tumors are associated with germline mutations of the SDHB gene. SDHB related pheochromocytomas and paragangliomas and many apparently sporadic tumors exhibit abnormal angiogenesis. This trial assessed the efficacy and safety of Cabozantinib, a potent, antiangiogenic, tyrosine kinase inhibitor. Methods: The Natalie trial is a single arm phase 2 clini...

Background: Metastatic pheochromocytomas and paragangliomas are rare neuroendocrine tumors with limited treatment options. We studied the efficacy and safety of off-label High-Specific-Activity I-131-meta-iodobenzylguanidine (HSA-I-131-MIBG) in routine clinical practice. Methods: This is a retrospective cohort study. The primary endpoint is objective response rate (ORR) as per RECIST v1.1. Secondary endpoints are blood pressure control, safety, overall a...

Neurosteroids refer to hormones with a steroid structure and, their synthesis pathways are identical to those of traditional steroids. However, neurosteroids are generated denovo in the central and peripheral nervous systems and utilize cell surface receptors. Few animal studies indicated synthesis of NS in pituitary. Presence of neurosteroids in human pituitary adenomas(PAs) has yet to be assessed. This is preliminary data of an ongoing study. Seventyseven specimens from huma...

Introduction: Malabsorption of levothyroxine is an important clinical problem. Changes in gastric pH due to various medical conditions might cause challenges in maintaning normal TSH values.Case: A forty-nine years old female who has been followed up with a diagnosis of primary hypothyroidism for 12 years admitted to our outpatient clinic with a complaint of unachievement of euthyroidism despite increasing the levothyroxine dose up to 200 mg. He did not ...

Purpose: The association between differentiated thyroid cancers and autoimmune thyroid diseases is well known. Therefore, we aimed to investigate the importance of thyroid peroxidase antibody (anti-TPO) and thyroglobulin antibody (Anti-Tg) in patients followed with the diagnosis of Hashimoto’s thyroiditis regarding the development of differentiated thyroid cancer.Methods: A total of 56 patients including 22 Hashimoto’s thyroiditis patients oper...