Endocrine Abstracts

Radioactive iodine therapy (RAI) is a treatment method used to in cases of Graves’ disease(GD), toxic multinodular guatr and solitary toxic nodüle and residual tissue after thyroidectomy or in the treatment of metastases capable of capturing iodine. The biological basis of the treatment is the inhibition of follicle cell functions. Side effects such as thyroid swelling, radiation thyroiditis and sialadenitis are rare. Radiation thyroiditis tends to occur within two w...

Introduction: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. To understand the molecular mechanism governing the function of EECs, it is important to investigate cell-type-specific gene expression. The aim of this study was to identify the transcriptome of human EEC populations from organoid culture.Methods: To label the f...

Introduction: A pituitary adenoma is directly assumed to originate from anterior pituitary. It is expected that pathologies of posterior hypophysis cause diabates insipitus (DI). However recently posterior pituitary tumors (PPTs) are also declared which are not associated with DI in contrast to what is expected. Rather they have a clinical and radiologic presentation akin to anterior pituitary adenomas. Differentiation of two conditions is mainly based on pathologic immunohyst...

Introduction: The Dandy-Walker complex (DW) comprises a rare intracranial malformation of the posterior fossa and multiple organ anomalies. The association with endocrine pathology is rare - described in isolated cases (Kallman syndrome, primary hypothyroidism (PH) and central precocious puberty). Noonan syndrome (NS) is a genetic disease usually diagnosed at birth, with variable phenotype. Most cases have AD transmission, with the PTPN11 gene mutation responsible for 50%....

Aim and Introduction: Peripheral giant cell granulomas (PHDG) are uncommon exophytic lesions of the oral cavity that originate from the periosteum or periodontal membrane as a polypoid mass. Mandibular involvement is more common than maxillary involvement. Patients with primary hyperparathyroidism can infrequently exhibit PHDG in the early stages of the disease. We wanted to present our case who was examined for giant cell granuloma developing in the mandibula and was found to...

Objective: The study aims to investigate the association between asymptomatic pyuria/bacteriuria at the initiation of SGLT2 inhibitors (SGLT2i) and urinary tract infection (UTI) risk in a cohort of women with type 2 diabetes mellitus (T2DM) (NCT05520684).Methods: The female outpatients with T2DM under follow-up in the department of internal medicine and initiated SGLT2i (dapagliflozin/empagliflozin) were included between February and September 2022. Excl...

Introduction: The main goal of treatment in Cushing’s disease (CD) is to induce remission as well as to restore reproductive function. We aimed to evaluate the reproductive status of the female patients with CD encountered in sexually active patients after surgical with/without medical treatments.Method: The retrospective data was obtained from the medical records of the 72 female patients diagnosed with CD at hospital registration system. The patie...

Introduction: Although the thyroid isthmus seems like a structure that connects bilateral lobes, it is an undiscovered area that needs to be explored. Currently, the data is evolving that the increase in the risk of malignancy is higher in the isthmic nodules, and extrathyroidal extensions and lymph node metastases are more common in isthmic-derived malignant thyroid nodules. Therefore, we aimed to compare the malignancy rate of isthmic and lobar nodules, the ultrasonographic ...

Background: Radioiodine (RAI) therapy has been used for a long time in benign and malign diseases of the thyroid gland. During the application of radioiodine treatment, parathyroid glands may also be exposed to radiation due to its close proximity to the thyroid gland. There is interest in the effects of RAI treatment on parathyroid functions in clinical studies. The aim of this study is to evaluate whether the dose of RAI treatment for benign or malignant thyroid diseases has...

Aim: Serum sclerostin levels as an indicator of bone resorption in children with congenital adrenal hyperplasia (CAH) have not been evaluated to date. The aim of this study was to determine the role of osteoprotegerin (OPG) and sclerostin in bone metabolism in children with CAH.Methods: Thirty-one patients (19 girls, 12 boys) with CAH (aged 11.6±3.7 years) and 31 healthy children (age- and sex-matched) as controls were included in the study. The patie...