Endocrine Abstracts

Background/Aim: Neuroendocrine tumors (NETs) are rare tumors arising from neuroendocrine cells throughout the body. Positron Emission Tomography (PET) scanning with 6-[18F]fluor-L-3,4-dihydroxyphenylalanine (18F-FDOPA) has been shown to be a valuable technique for the imaging of NETs. While the sensitivity has been assessed numerously, studies systematically describing false positive results, other than physiological variants, are lacking. Our aim was to systematica...

Introduction: Epigenetic is acquiring great importance in complex diseases, providing mechanisms whereby environmental factors can influence complex diseases such as obesity and type 2 diabetes. Experimental animal and human studies have revealed the association between SCD1 and obesity and insulin resistance. The aim of this study was to evaluate whether metabolic changes after intervention are associated with DNA methylation pattern and if these changes are related to weigh ...

As the nation gets fatter, the incidence of diabetes is also rising. The brain is now emerging as a critical mediator of blood sugar control, re-directing focus away from the traditional pancreas-centred model. The enzyme glucokinase (GK) acts as a glucose sensor in many tissues including glucose-sensitive neurones within the hypothalamic arcuate nucleus. However, the role of GK here is unclear. We investigated the role of arcuate GK in glucose homeostasis in both healthy and ...

Background: FGF21 is a critical metabolic regulator with beneficial effects on lipid and glucose metabolism. FGF21 is produced primarily by the liver and stimulates fatty acids oxidation, which prevents hepatic triglycerides accumulation and nonalcoholic fatty liver disease (NALFD). FGF21also increases insulin sensitivity and glucose uptake in adipose tissue. Paradoxically FGF21 is elevated in insulin resistance states e.g. NALFD, obesity and type 2 diabetes. It is not determi...

Introduction: The mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood. The function of adrenal axis requires special attention.Aim: To investigate the time/mode/markers of pituitary function deterioration in families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed retrospective longitudinal (36.4 years, s.d. = 13.6) analy...

Background: Hypopituitarism is a condition caused by deficiency in one or multiple pituitary hormones. The disease is associated with various metabolic disorders and decreased quality of life that are particularly marked in patients with childhood onset of the disorder. There are manyfactors influencing the metabolic status of patients such as different treatment modalities (surgery, radiotherapy, chemotherapy) and current supplementation (e.g. steroid or testosterone/estradio...

Background: Pituitary stalk lesions (PSL) is a general term used to describe changes located in the pituitary infundibulum. Special anatomical locus makes the diagnosis difficult to establish. Most of the patients with PSL characterizes with hypopituitarism and multiple metabolic abnormalities.Aim: To present the characteristic of patients with PSL.Methods: We analyzed data of 35 patients (21 M/14 W) with pituitary stalk ...

Introduction: Pre- and postsurgical differentiation between follicular thyroid adenoma (FTA) and follicular thyroid cancer (FTC) represents a significant diagnostic challenge. Typical markers of malignancy may appear as specific genetic alterations. Next-generation sequencing (NGS) studies bring information about single point mutations, however better insight into follicular thyroid lesions genetic landscape, encompassing bigger rearrangements, is needed.<p class="abstext"...

It is important to know the prevalence of common diseases in every country in order to guide us to take decisions regarding public health benefits in screening, in Mexico we do not have information regarding thyroid abnormalities.Methods: We designed a cross-sectional study in the city of Queretaro (Mexico) in order to know the prevalence of altered thyroid function tests in our population, since we do not have any previous study. We calculated the sampl...

Background: Kisspeptin is a critical regulator of normal reproductive function. In humans inactivating mutations of the kisspeptin receptor GPR54 cause hypogonadotrophic hypogonadism and pubertal failure. Activating mutations of GPR54 cause precocious puberty. Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. In rodent models of HA hypothalamic KISS1 expressi...