Endocrine Abstracts

MEN1 is an autosomal dominant endocrine tumour syndrome, caused by inactivating mutations of the MEN1 tumour suppressor gene at 11q13 locus and characterised by occurrence of hyperparathyroidism, pancreatic tumours and pituitary adenomas. We describe a family with MEN1 syndrome. The index case was a 71-year-old man, referred to Endocrinology clinic in Midland Regional Hospital Portlaoise for hypercalcemia (calcium 3 mmol/l, phosphate 0.5 mmol/l, PTH 350 pg/ml, creatin...

We present a 41 years old lady who presented with non specifc symptoms- lethargy, general myalgia, memory impairment. She also complained of hot flushes, sweats and had a brief episode of panic attacks hence was commence on Sertraline by the GP. She has a past medical history of appendicectomy. Her mother had lymphoma and mother died from lung cancer. She is a smoker, however is teetotal. She has 3 children and works in a laundry. She was initially referred to the haematologis...

Von Hippel–Lindau (VHL) disease, attributable to germline mutations in the VHL gene on the short arm of chromosome 3 (3p25-26) is an inherited condition which can give rise to paragangliomas. We present a case of 47 year old gentleman with bilateral pheochromocytomas in the past resulting in both adrenalectomies as a child in the 1980. His routine follow up subsequently picked up elevated urine Normetanephrines at 14.3 µmol/24 h 25 years postoperatively. His CT abdo...

The incidence of type 1 diabetes mellitus (T1DM) is rising. The demands of daily management, blood glucose variability and potential complications pose challenges in management of T1DM.The aim of this study was to determine the clinical and metabolic profiles of T1DM patients attending Midland Regional Hospital Portlaoise diabetes service in 2017 and to assess their microvascular and macrovascular complications.A retrospective anal...

We present a case of a 24 year old lady with known SDHB mutation. She was referred from the genetics clinic in view of a strong family history of premature paraganglioma at the age of 17. On initial clinic assessment she exhibits no symptoms suggestive of paraganglioma or pheochromocytoma. Her blood pressure is normal at 120/75. pulse of 60–80bpm. Physical examination was unremarkable Her Plasma normetanephrine done on two separate occasion were elevated at 1600 pmol/l a...

Objective: A descriptive study to summarize the experience on diagnosis of NET using various imaging modalities.Methods: Imaging was reviewed for 25 patients between 2002 and 2009 (22 MEN-1, 3 sporadic insulinoma). Of 13/25 had elevated fasting gut hormones. CT, MRI, endoscopic ultrasound (EUS), somatostatin receptor scintigraphy (SRS) and angiography were reviewed. (CT, MRI examined with arterial enhancement).Results: Most frequen...

We have previously attributed the hypoglycaemic effects of Syzygium cordatum leaf extract to crude ethyl acetate extract solubles (EAS) containing triterpenoid compounds. The present study was designed to isolate and characterize triterpene components EAS and investigate the antihyperglycaemic effects alone or in combination with insulin in non-diabetic and streptozotocin (STZ)-induced diabetic rats. EAS soluble extracts were obtained after defatting the S. cordatum<...

Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst.) (Myrtaceae) leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (OA) and ursolic acid (UA). For the bioactive compounds to have potential in diabetes management, they should also alleviate or prevent complications of diabetes mellitus; kidney function and cardiovascular disorders. This study i...

Background: In the first trimester, the foetus is dependent on circulating maternal thyroid hormones for normal brain development. Maintenance of euthyroidism is important throughout pregnancy and maternal hypothyroidism is associated with adverse foetal outcomes.Aim: To audit the management of pregnancies complicated by hypothyroidism in a joint antenatal endocrine clinic in comparison with the UK guidelines from the British Thyroid Association (2006).<...

A 63-year-old gentleman with hypopituitarism secondary to non-functioning pituitary macro adenoma, treated with trans sphenoidal surgery 16 years earlier, was admitted with chest pain. His ECG showed 3 mm ST elevation in the inferolateral leads, and his subsequent cardiac enzymes were consistent with acute myocardial infarction. A decision was made not to thrombolyse him, as any intracranial tumour is an absolute contraindication to thrombolysis. He was discussed with the tert...