Endocrine Abstracts

A 64 old year old obese (BMI 31 kg/m2) Caucasian male was admitted to our hospital with general malaise, nausea, vomiting and dehydration. He gave no preceding history of polyuria, polydipsia or weight loss. He had been receiving oral corticosteroids for established ulcerative colitis. He was found to have random plasma glucose of 70.7 mmol/l, positive serum and urine ketones, and metabolic acidosis with PH 7.27, bicarbonate 13 mmol/l and base excess −12.4. Th...

BackgroundAppetite is complex, however to address the obesity epidemic, therapeutic agents would have to significantly influence appetite. Currently the most effective treatment for obesity is bariatric surgery because it reduces hunger and increases satiety. The satiety gut hormones such as peptide YY (PYY) and glucagon like peptide 1 (GLP-1) reduce appetite and food intake. Compared to lean and obese subjects, exaggerated postprandial responses of PYY ...

The integrity of bone marrow and its various haemopoeitic cells require several hormones including sex steroids. Sex steroids were used in the past to treat aplastic anaemia. A 27 years old Saudi male who underwent a resection of hypothalamic astrocytoma and developed panhypopituitarism was admitted to ICU with shunt related meningitis and noted to have thrombocytopenia of 90,000 anemia of 9.5 gldl, which progressed over the subsequent week following admission. He recovered fr...

The study presents the outcome of determination of serum VEGF and sVCAM in 58 patients (43 women and 15 men aged 20–76 years) with adrenal tumors: adrenal cortical adenoma (34), adrenal cortical carcinoma (12), pheochromocytoma (9), myelolipoma (2) and lymphangioma (1). Control group comprised 25 practically healthy volunteers (13 women and 12 men aged 17–67 years). Serum VEGF was measured by enzyme immunoassay using reactants from ‘R&D’ (USA), sVCAM &#...

Background and Aims: Components of metabolic syndrome (MS) carry an increased risk for cardiovascular disease (CVD). People with abnormal glucose regulation are more prone to develop complications. At diagnosis 20-30% of type 2 diabetic (T2DM) patients (pts) already have neuropathy-one of the most dangerous complications. Cardiac autonomic neuropathy (CAN) is associated with five-fold risk of mortality. Our aim was to study possible relation between CAN and some components of ...

Much has been written on the attributes of preoperative localisation and minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism. A recent 'summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century' (Bilezikian et al, 2002) suggested however that in experienced hands, conventional open parathyroidectomy with visualisation of all four glands was still the gold standard. In light of this we have carried o...

BackgroundSodium glucose cotransporter-2 (SGLT-2) inhibitors have proven valuable in the management of type 2 diabetes. These agents are particularly effective in reducing hospitalisations with heart failure and cardiovascular mortality. Adverse effects are primarily centred on urogenital infections and hypovolaemia. Here, we report the case of a patient who developed asymptomatic erythrocytosis while taking empagliflozin.Case repo...

IntroductionMultiple Endocrine Neoplasia type-1 (MEN-1) is an inherited autosomal dominant condition with a high degree of penetrance characterized by tumour occurrence in the form of pancreatic neuroendocrine (pNET), parathyroid and anterior pituitary gland tumours, among others. Treatment for MEN-1 associated endocrine tumour, particularly pancreatic, is more challenging than in those without MEN-1, given its multicentric nature and aggressive behaviou...

Giant prolactinomas are rare tumours, accounting for only 2–3% of all prolactin (PRL)-secreting tumours which can pose therapeutic challenges. It has a higher preponderance in men with a male to female ratio of about 9:1. A 70year old gentleman initially presented to the ophthalmology department with blurred and reduced colour vision. He denied any headache, galactorrhoea or gynaecomastia however he noticed reduced libido and difficulties with erections. His past medical ...

Currently, acromegaly is treatable by 3 groups of drugs available for the treatment of acromegaly: dopamine agonists (DA), somatostatin analogues (SRL) and a growth hormone receptor blocker (GH receptor antagonist GHRA). More recently, pasireotide and pasireotide-LAR were developed as multi-receptor targeted SRLs with higher potency than 1st generation SRLs/octreotide-LAR and lanreotide/and until now were considered second generation SRLs. Pasireotide, unlike first-generation ...