Endocrine Abstracts

Objective: Both MODY and GDM are characterized by pancreatic beta cell dysfunction. The study aimed to first investigate the associations between miR-SNPs of HNF4A, HNF1A and HNF1B genes and the GDM susceptibility and lipid profiles.Methods: The software PolymiRTS were used to screen miR-SNPs. Genotyping of SNPs was performed with TaqMan allelic discrimination assays in 839 GDM patients and 900 controls. Multivariable logistic ...

Nutrient sensors mediating the stimulatory effects of food-derived carbohydrates and lipids on incretin and insulin secretion have been widely studied. However, mechanisms underlying amino acid regulation of those processes remain poorly understood. GPR142 was recently reported to be highly expressed in pancreatic beta cells and selectively activated by L-Tryptophan (L-Trp). Moreover, synthetic GPR142 agonists were demonstrated to stimulate glucose-dependent insulin secretion ...

Objective: HNF1A gene mutations are the most common cause of monogenic diabetes. Patients with HNF1A–MODY display sensitivity to sulphonylurea therapy, however the long term efficacy has yet to be established. There is also limited literature as to the prevalence of complications in this unique cohort. The aim of the study was to determine the natural progression of HNF1A–MODY diabetes in a dedicated MODY clinic.Design: n=60 H...

Diabetes mellitus is currently being recognised as a global health problem. The likelihood of periodontal disease among diabetics is thrice and progresses rapidly when uncontrolled. Diabetics were less likely to see a dentist than to seek consult with a doctor for diabetes care. A cheap and easy way of clinical assessment via self-reported oral health questionnaire would be of great use especially in a developing country like The Philippines. This study aims to validate self-r...

Introduction: We wanted to analyse the pathology results of thyroidectomies performed in the hospitals of Castilla La Mancha (Spain) between the years 2010 and 2013, inclusive.Material and methods: A retrospective, multicentre, descriptive study of the histopathological results of the 1567 thyroidectomies performed in the hospitals of the eight health districts in our region between the years 2010 and 2013.Results: The histopatholo...

Introduction: Sensitivity and specificity of thyroid cytology in our series of thyroidectomies were evaluated.Material and methods: A retrospective, multicentre study of 1567 thyroidectomies performed in the eight hospitals of Castilla La Mancha (Spain) during the years 2010–2013.Results: The cytological results were benign in 37.6% of cases, malignant or suspicious of malignancy in 17.3% (10 and 7.3% respectively). In 4.1% of...

Introduction: Retrospective study of patients undergoing thyroid surgery at the Hospital Virgen de la Luz, Cuenca (Spain) during the years 2010–2013.Material and methods: We evaluated data of 92 patients basically with nodular thyroid disease, who were studied and treated in our hospital.Results: Our series is made up of 92 patients (25% men and 75% women) with an average age of 52 years. The most common form of presentation (...

Introduction: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterised by ACTH resistance and isolated glucocorticoid deficiency. Mutations of ACTH receptor, known as melanocortin-2 receptor (MC2R), and melanocortin-2 receptor accessory protein (MRAP) account for approximately 25 and 15 to 20% of cases respectively. To date there is no strong evidence that heterozygous carriers have abnormal cortisol secretion.Case: We...

Liquorice is a sweetener found in many food products, soft drinks, snacks and herbal medicines. Liquorice ingestion is an uncommon cause of AME or pseudohyperaldosteronisim. The mechanism involves the inhibition of 11-beta-hydroxysteroid dehydrogenase type-2 by the active ingredient called glycyrrhizin, which leads to the uninhibited activation of mineralocorticoid receptors by cortisol. Confectionary products that contain liquorice are readily available in the European Union....

Adipokines belong to a group of proteins involved in the pathogenesis and progression of immune/inflammatory diseases. It is an open question whether and how adipokines contribute to these diseases. Adiponectin might be a key regulator of the immune system, playing a role in the progression of inflammatory disorders. Omentin has been recognized as an anti-inflammatory adipokine with influence on immune response regulation and inflammation, Systemic sclerosis (SSc) is a chronic...