Endocrine Abstracts

Objective: The aim of our study was to investigate the characteristics of the acromegalic patients followed at a tertiary Universitary Hospital and to evaluate the results of the recommended treatment protocols.Patients and methods: All our acromegalic patients were included (n=48; 27 women). Demographic, hormonal, visual and imaging data at diagnosis and during follow-up, as well as treatments applied, were recorded.Results...

BackgroundSR141716 (Rimonabant) has been shown to significantly inhibit food intake and reduce body weight in rodents and humans by antagonising CB1 receptors. The gut hormones peptide YY3–36 (PYY3–36) and oxyntomodulin (OXM), released from L-cells in the small intestine inhibit food intake in both rodents and humans and this effect is thought to be mediated via the hypothalamus.Objective<...

Paraganglioneuromas producing predominantly dopamine are very rare. Such tumours are potentially malignant and often tend to have atypical clinical presentation. Majority of the patients are normotensive and tumours are detected incidentally on imaging studies. We report a case of dopamine secreting – malignant paraganglioneuroma with spinal metastasis. A 65-year-old man was referred to the endocrinology clinic after an incidental finding of large right para-adrenal mass ...

Endocrine manifestations of arachnoid cysts, including suprasellar arachnoid cysts(SAC) are not well recognized. The effect of neurosurgical interventions on such manifestations is also not well reported. Here in we report a case of a young man with hypothalamic dysfunction secondary to SAC who made a good recovery after surgical treatment of the cyst.A 22-yr-old man was referred to our endocrine clinic for evaluation of progressive weight loss and malai...

Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake.Objective: To examine the effect of NPS on the regulati...

Background and Aims: There are consistent findings about increased prevalence of depressive disorders in diabetes. The aim of the study was to reveal prevalence of depression in patients (pts) with type 1 (DM1) and type 2 (DM2) diabetes.Materials and Methods: Totally, 157 pts with DM were questioned. To assess depression degree Beck’s scale was used, and 83 depressive pts (scores >10), were allocated into 2 groups (Gr.): Gr.1 (n=44)–...

VEGF exerts its effects by binding to two tyrosine kinase receptors, KDR and VEGFR1. KDR is critical for transmitting signals for proliferation and migration of endothelial cells but is also expressed in several non-endothelial cells, and is elevated in some human tumour cells. We investigated KDR expression in human thyroid epithelial cells in vitro and thyroid cancers compared with normal thyroid samples examined ex vivo. Expression of KDR was demonstrated usin...

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...

The increased appetite associated with hyperthyroidism is assumed to be secondary to an increased metabolic rate. However, the role of thyroid hormones in appetite regulation is poorly understood. We hypothesised that thyroid hormones directly regulate food intake and studied the effects of peripheral and CNS administration of tri-iodothyronine (T3) on food intake in male Wistar rats in vivo.A single subcutaneous (s.c.) injection of 4.5 nmol per ...

This 24-week, multicentre, open, parallel group study compared the efficacy and safety of two different regimens for initiating insulin therapy. Insulin-naive patients with fasting blood glucose (FBG) levels >=6.7 mmol/L (>=120 mg/dL) and HbA1c levels 7.5-10.5% on oral antidiabetic agents (OADs: glimepiride [Amaryl] or other sulfonylureas plus metformin) were randomized to insulin glargine (LANTUS) once daily in the morning with continued OADs (Glarg + OADs) o...