Endocrine Abstracts

Introduction: Chronic hypercortisolemia during Cushing Syndrome (CS) determines significant changes in the plasticity and function of metabolic tissues like visceral adipose tissue (VAT). Persistence of alterations in VAT function after CS remission is under debate, as data of clinical studies is not consistent due to confounder factors and limited availability of VAT. Animal model of reversible CS presents long-term alterations on VAT after remission. We investigate VAT alter...

Introduction: Blastocystissp. (BS) is the most common intestinal parasite that is isolated in human fecal samples. Its pathogenic role is still questioned. While some consider it a beneficial component of the human intestinal microbiota, some evidence relates it with dysbiosis and development of metabolic syndrome (MS). Its presence has been inversely correlated with BMI.Objective: The objective of this study is two-fold: determining the prevale...

Introduction: Cyclic Cushing´s syndrome (CCS) is a rare disorder with a wide clinical variability, characterized by repeated episodes of cortisol excess and periods of normal or even low cortisol secretion. Different periodical diagnostic tests are required to confirm hypercortisolism and thereafter imaging techniques and laboratory studies can be performed to localize the cause.Case report: A 17-year-old female patient with a personal history of ad...

Introduction: Growth hormone deficiency (GHD) is associated with worsening body composition and growth hormone replacement therapy (GHRT) has shown to improve it in several studies. The objectives of this study were to evaluate the effects of long-term GHRT on body composition in adult patients with GHD andassess, in this population, the agreement between two different methods to measure fat mass that are total body fat mass (FM) and relative fat mass (RFM).<p class="abste...

Introduction: The use of iSGLT2 continues to be controversial in diabetic patients with peripheral arterial disease.Objectives: Assess the metabolic effect and the risk of amputations of iSGLT2 in diabetic patients cared for in the Multidisciplinary Diabetic Foot Unit (MDFU) compared to a control group.Material and Methods: A retrospective observational study where patients attended at the MDFU from December 2017 to January 2020 we...

Objective: Cushing’s disease (CD) is difficult to diagnose because of its rarity and because its most common symptoms can overlap with those of other more common conditions. Remission rates in the postoperative vary between 55–85%. Overall, the mean time to diagnosis was 38 months. The objective of this study was to describe whether there is any pre-surgical clinical data that predicts CD remission after TSS.Patients and Methods: Retrospectiv...

Objectives: To describe the results of the bilateral inferior petrosal sinus sampling (BIPSS) performed in our hospital for differential diagnosis between Cushing disease (CD) and ectopic ACTH secretion (EAS), and evaluate if CRH stimulation during this test improves its diagnostic accuracy.Material and Methods: We retrospectively review 29 BIPSS performed in 26 patients (4 men, 22 women), with mean age of 44.7 year-old (range 28–69), diagnosed wit...

Objective: Remission of Cushing’s disease (CD) in the postoperative vary between 55–85%, recurrence of up to 25%. Remission and recurrence rates vary dependent on tumor size and neurosurgical expertise. The objective of this study is to describe whether there are clinical data that help us to predece recurrence of CD after transsphenoidal surgery (TSS).Patients and Methods: Retrospective analysis of patients who underwent as TSS for CD. Varia...

Background: The increased incidence of metabolic syndrome (MetS) is one of the causes of expansion of Type II diabetes and cardiovascular disease. Persons with Mets have higher chance of suffering a cardiovascular disease and dying from this cause that people without this disorder.The MetS is characterized by glucose intolerance, dyslipidemia, obesity and hypertension. In certain populations has a high prevalence rate, exceeding 20%.<p class="abstext...

Background: Cardiovascular disease (CVD) is the major cause of premature mortality throughout the western world and a major cause of disability. Most cases of CVD are related to lifestyle behaviors, biochemical and physiological factors modifiable. The modification of cardiovascular risk has shown its ability to reduce mortality and morbidity from CVD, particularly in high-risk subjects.Objective: Measuring cardiovascular risk at 5 and 10 years in a work...