Endocrine Abstracts

Background: Immune related adverse events (iRAEs) of the endocrine system are commonly recognised in Checkpoint Inhibitor (CTLA-4 and PD-1 inhibitors) Therapy. Clinically, endocrinopathies can present with symptoms of hormone deficiency, hormone excess or both (in the same or different glands).Aim: Audit of Incidence and Management (detection, investigation, referral and management) practices of Endocrinopathies due to Immunotherapy in Oncology departmen...

Case: A 42-year old woman was referred to the endocrinology department for polydipsia and polyuria of sudden onset one month prior to presentation. She drank between 8 and 10 litres of water per day and complained of thirst, asthenia and lighter menstruation under her usual oral contraceptive pill. In addition to contraception she took 50 μg of L-thyroxine for Hashimoto thyroïditis. She had also a medical history of pink-red cutaneous lesions evolving for more than 1...

The article is devoted to one of the most pressing medical problems – diabetes mellitus type 2.Objective: To study the peculiarities of the course of diabetes mellitus type 2 in persons over 65 years of age; to evaluate the effectiveness of different therapy regimens for the level of HbA1C.Material and methods: The retrospective study included 100 patients with type 2 diabetes (T2D). The age of the patients: 65 to 82 years. Th...

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

Objective: By the definition of vitamin D receptors in many tissues, many functions of vitamin D other than calcium homeostasis and bone metabolism were shown. A role for vitamin D is suggested in the pathogenesis of Graves disease because of the effects of vitamin D on the immune system. In our study the role of vitamin D deficiency in the activation of Graves disease, development of autoimmune thyroid disease and the relationship between vitamin D and inflammatory markers we...

Introduction: This audit aims to evidence the compliance of our practice with guidelines on the management of thyroid cancer. This may help to promote quality improvement in areas where there is substandard clinical care and service provision.Method: In this retrospective study, patients diagnosed with thyroid cancers at our unit between 2009 and 2014 were identified. Electronic records were examined to establish the dates of referral, clinic attendance,...

Introduction: Juvenile thyrotoxicosis is treated with anti-thyroid drugs using a block and replace or dose titration regimen. There is a high rate of relapse and majority require definitive treatment with surgical or radio-iodine ablation. Increasingly radio-iodine therapy is being used in children, particularly in the USA, but experience with this is limited in the UK. In our unit we have an experienced paediatric thyroid surgeon and we have always carried out surgery in chil...

Research objective: To estimate efficiency of metformin use in children and teenagers with metabolic syndrome (MetS).Materials and methods: Eighty children and teenagers aged 10–16 with exogenous-constitutional obesity (ECO) were observed. From them in 19 (23.8%) MetS was diagnosed according to diagnostic criteria of IDF (2007); 15 of them (78.9% – seven boys and eight girls) were prescribed metformin (Siofor, Berlin Chemie) in dose from 1000 t...

Cushing’s syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing’s associated with markedly raised ACTH and cortisol levels. This leads to an impaired immune response, setting the stage for occurrence of opportunistic infections. Nocardia is a gram positive bacterial infection caused by aerobic actinomycetes in genus Nocardia. We report a series of patients diagnosed with ectopic Cushings, with growth o...