Endocrine Abstracts

Background and Aims: Recent studies have suggested that maternal thyroid dysfunction, particularly in early pregnancy, may have a detrimental effect on the neuropsychological development of offspring. In the light of these studies a local guideline was drawn which recommended screening thyroid function at booking in all pregnant women with a personal or family history of thyroid disease. The aims of this study were to assess adherence to this guideline, and to test its efficac...

Introduction: Premature newborns are defined as babies born before 37 weeks of pregnancy and after 22 weeks of pregnancy as a viability limit. This study aimed to analyse growth characteristics at the age of second and third age and the prevention of metabolic diseases that may occur in adult age at an early phase.Methods: This study was conducted as a retrospective cohort study between May 2021 and October 2021 in 18 different Outpatient Clinics in Patn...

A 32-year-old gentleman, of South-Asian origin was admitted with a 4-week history of abdominal pain, nausea and vomiting. He also had history of polyuria, polydipsia and weight loss over 6 weeks. Just prior to these symptoms he had been started on colecalciferol 20 000 units weekly by his GP for Vitamin D deficiency (25(OH) Vitamin D – 10.3 nmol/l (48–145)). On admission he had adjusted calcium of 4.52 mmol/l and acute kidney injury with his eGFR being 38 ml/min per ...

A 37-year-old gentleman was admitted following a GP referral for asymptomatic hypercalcaemia. His adjusted calcium was raised at 3.27 mmol/l while phosphate level was normal. The only past medical history was borderline hypertension which was being monitored in primary care. His PTH level was suppressed at 0.43 pmol/l l (1.1–5.5) while 25(OH) Vitamin D was normal at 71.6 nmol/l (48–145). Twenty-four hours urinary metadrenalines were normal. His full blood counts were...

Introduction: Non-functioning pituitary adenomas, usually macroadenomas, represent around 30% of pituitary tumors. Patients often present with signs of mass effect and symptoms of pituitary insufficiency. We report a complicated case of a cystic pituitary ‘macroadenoma’ presenting with recurrent mucocoeles likely due to underlying sinusitis.Case report: A 42-year-old Caucasian female presented with chronic headaches and unilateral temporal visu...

Introduction: Primary and secondary hyperparathyroidism may coexist unrelated to chronic nephropathy. It can occur more often than expected, especially in elderly population with malabsorption syndrome or /and liver diseases.Case report: A women 60 years of age was admitted to hospital due to long standing ostealgia. The primary hyperparathyroidism was suspected. The medical history presented recently diagnosed coeliac disease and cryptogenic hepatic cir...

Introduction: Anaplastic thyroid carcinoma (ATC) is characterized by an aggressive clinical course and refractoriness to currently available local and systemic modalities of treatment. It is considered the most aggressive solid tumor, with few patients alive more than 1 year following diagnosis.Bible et al have reported a combined therapy of radiation and radiosensitizing adjuvant chemotherapy, with some positive results.Case repor...

Background and Objectives: Different definitions for the metabolic syndrome (MS) exist.Established criteria for diagnosis includes: raised blood pressure, dysglycemia, dyslipidemia, and obesity, but the used thresholds differed. Individual patients with MS need to be identified to reduce future complications. We aimed to determine the characteristics of subjects identified from healthy population to have MS by NCEP-ATP III, IDF and the consensus definition by IDF and AHA/NHLBI...

Introduction: Vitamin D is suggested to be an inhibitor of angiogenesis. The degree of severity of Diabetic retinopathy (DR) may be related to serum Vitamin D concentration so this study aims at investigating vitamin D and parathormone (PTH) concentrations as predictors of the development and severity of diabetic retinopathy.Material and methods: Levels of vitamin D [25(OH) D3 and Calcitriol] and PTH were measured in 200 diabetic patients presenting with...

Hypoglycaemia is a one of the commonest presentation of an ill child. Hyponatraemia during illness is mostly presumed to be related to syndrome of inappropriate anti diuretic hormone secretion (SIADH). We would like to present an interesting case of hypoglycaemia and hyponatraemia.A four-year-old boy presented with a two-day history of intermittent fever, vacant episodes, and seizures. He was noted to be hypoglycaemic with laboratory glucose of 1.2 mmol/...