Endocrine Abstracts

Introduction: In 1960, Van Wyk and Grumbach described the association of hypothyroidism and precocious puberty. Hypothyroidism leads to delayed bone age and a reduction in growth rate by reducing the amplitude of GH pulses. When precocious puberty is associated with thyroid hypofunction, estrogen action on the epiphyseal plates reduce this delay. We report the case of a child who developed incomplete puberty and reduced growth rate, caused by primary hypothyroidism.<p clas...

Introduction: Thyrotoxic hypokalemic paralysis is a disorder most commonly seen in Asian men. The condition primarily affects the lower extremities. The main characteristic features of this condition are elevated thyroid hormones, hypokalemia and proximal muscle weakness or paralysis.CasesCase 1: A 28 year old patient presented to emergency department with 3 day history of progressive weakness of both lower limbs which made him una...

A 28 year old female with no significant medical history, 25 weeks into her second pregnancy was referred to endocrinology with adjusted calcium of 2.99 mmol/l. She had a short history of generalised aches and tiredness. Examination did not reveal any stigmata of MEN1 or the HPT-JT syndromes. There was no known family history of endocrine disorders. Her PTH was 7 pmol/l, confirming primary hyperparathyroidism. As parathyroid Tc-scintigraphy would be contraindicated in pregnanc...

Mitochondria oxidize food substrates to generate energy for cellular work and heat is variably generated depending on the degree of coupling of electron transport to oxidative phosphorylation (OXPHOS). It has been hypothesized that climatic pressures exerted selection for mitochondrial haplogroup in arctic populations for a lower coupling of mitochondrial respiration to ATP production in favor of heat production. In this study muscle mitochondrial function was studied in Inuit...

Introduction: Responsible use of healthcare resources dictates that judicious test ordering be encouraged. Although the appearance of anti-GAD antibodies is known to precede and predict the development of autoimmune diabetes, its use as a screen for risk of developing diabetes is not warranted. Results are useful in determining treatment, however, when it is difficult to distinguish type 1 from type 2 diabetes or when the probability of progression from type 2 to type 1 is hig...

Background: Patients with type 2 diabetes mellitus (T2DM) have elevated risk of coronary artery disease (CAD) development. In this population CAD often proceedsasymptomatically, especially if cardiac autonomic neuropathy (CAN) is present. Our aim was to assess relation between glycemia control and asymptomatic CAD inT2DM pts. Materials and methods: Participants were 160 T2DM patients without documented CAD divided into four groups (Gr.) according to HbA1c levels: Gr. 1 -HbA1c6...

Introduction: Although skin tag is associated with diabetes mellitus, no data in the literature show that the presence of skin tag is associated with diabetic macro and microangiopathy. The purpose of this study was to investigate frequency of hypertension, dyslipidemia, obesity, macro and micro angiopathy in type 2 diabetic patients with and without skin tag.Methods/Design: We evaluated 99 (40 female and 59 male) type 2 diabetic patients. All patients w...

Objectives: Oral administration of vanadate to diabetic animals have been shown to stabilize the glucose homeostasis and restore altered metabolic pathways. The present study explored the prospect of using low doses of vanadate with Trigonella foenum graecum, seed powder (TSP), another antidiabetic agent, and to evaluate their antidiabetic effect in diabetic rats. The effect of these antidiabetic compounds was examined on general physiological parameters, monoamine oxidase act...

Background and Aims: Diabetes causes immeasurable personal suffering and costs to the society, though diabetes and its complications are largely preventable. There are proven, affordable preventions available, that can stop or delay diabetes/complication development. Political Declaration adopted by UNO stresses importance of educational measures to promote health education and literacy. IMAGE Project/Toolkit on Type 2 Diabetes Prevention in Europe outlines education as corner...

Introduction: The insulin-like growth factor-I receptor (IGF-IR) plays a key role in regulating growth, survival and invasion of several human malignancies including prostate cancer. In prostate cancer cells, the IGF-IR expression is upregulated by androgens through a nongenotropic signaling unresponsive to antiandrogens and requiring AMP-response element-binding protein (CREB) activation. This mechanism sensitizes cells to the proliferative and protumor effects of IGF-I. Metf...