Endocrine Abstracts

Introduction: Brittle hypertyroidism is a term used for the clinical situation characterized by hypo-hyperthyroidism with antithyroid drugs, despite good compliance and follow-up. Here, we presented five patients suggested to have Brittle Graves.Case-1: Thyrotoxicosis was observed in a 57-year-old female patient and Graves was diagnosed after laboratory and imaging examinations 25 months after initiation of propylthiouracil 50 mg/day, she developed hypot...

Aim: Lithium bicarbonate is a drug used in the initial treatment of bipolar disorders. Lithium is an element of alcali metal group and besides being a causative agent for goiter and hypothyroidism primarily, it has also some antithyroid effects. Rarely, lithium may cause hyperthyroidism secondary to thyroiditis or probably autoimmune mechanisms. The association between lithium and thyroid cancer is very little known subject. In this case series, we presented differentiated thy...

Introduction: Acromegaly patients are known to have an increased risk of malignancies. This may be as a result of the effect of insulin-like growth factor I (IGF-I) on cellular proliferation and apoptosis inhibition. Although there are various reports related with hematological malignancies in children who treated with growth hormone (GH), few data are available about hematological malignancies in acromegaly patients. Here, we report a patient with acromegaly who has been deve...

Introduction: Thyroid tumors of uncertain malignant potential (TT-UMP) has been accepted as a subgroup of follicular-patterned thyroid tumors for which benignancy or malignancy cannot be assessed exactly. We aimed to evaluate demographic characteristics, ultrasound (US) findings, and cytological results of patients with TT-UMP and compare these findings with the classical variant of papillary thyroid carcinoma (CV-PTC) and non-encapsulated follicular variant of PTC (NEFV-PTC) ...

Introduction: Hyalinizing trabecular tumor is a very rare neoplasm of thyroid and can be misinterpreted as papillary or medullary cancer in fine needle aspiration biopsy (FNAB).Case report: Multinodular goiter was detected in a 65 years old woman using metformin and L-thyroxine for impaired blood glucose and Hashimoto thyroiditis, respectively. FNAB was performed in two nodules and reported as suspicious for malignancy and benign. She underwent total thy...

Introduction: Increasing evidence is available for the role of prolactin in the development of various cancers. The purpose of this study is to evaluate the frequency of thyroid cancer in patients with prolactinoma followed up at a single site.Materials and methods: Medical records of 182 patients, diagnosed with prolactinoma, were reviewed retrospectively. Out of these patients, 114 patients (103 female patients, 11 male patients, mean age 35±10.4)...

Riedel thyroiditis is a rare chronic inflammatory disease of the thyroid. It is characterized by replacement of normal parenchyma with dense fibrotic tissue. Peripheral tissues might also be affected and this may cause airway obstruction, dysphagia, recurrent laryngeal nerve palsy and hypoparathyroidism. We report a patient with toxic adenoma previously treated with radioactive iodine and histopathologically confirmed Riedel thyroiditis.Case: A 61 years ...

Introduction: Nowadays, ultrasonography (USG) is being used very commonly and indispensably for diagnosing thyroid diseases. Heterogeneous appearance of thyroid parenchyma is associated with positivity for thyroid autoantibody and hypofunctioning of thyroid gland. On the other hand, it is not determined whether thyroid parenchyma appearing totally of normal ecogenity on USG is related to presence normal thyroid function tests or otherwise. The objective of our study was evalua...

Aim: The relationship between hyperprolactinoma and insulin resistance has been shown in many studies. It is also known that hyperprolactinoma causes changes in carbohydrate and lipid metabolism. The aim of our study is to evaluate insulin resistance in patients with prolactinoma and see the effect of treatment on insulin resistance and karotis intima media thickness (CIMT).Material and methods: Twenty-two female patients diagnosed biochemically and radi...

Aim: Neopterin is a mareker of inflammation secreted from monocytes and macrophages. It is found to be increased in malignant diseases. The aim this study was to evaluate the urine neopterin levels in thyroid cancer.Materials and methods: Sixty nine patients with thyroid cancer, 76 patients with benign thyroid pathology and 33 healthy subjects were evaluated. First morning urine samples were collected from the patients and the normal subjects for neopter...