Endocrine Abstracts

Background: Non-functioning pituitary adenomas (NFPA) account for 30-35% of pituitary adenomas. They can lead to hypopituitarism and visual field defects. Trans-sphenoidal resection of pituitary adenoma remains the treatment of choice.Methods: We compared clinical, biochemical, and imaging characteristics of NFPAs at presentation with post-surgical outcomes in a retrospective cohort study. Patients who underwent end...

Background: Immunotherapy mediated adrenocorticotrpic hormone (ACTH) deficiency is an important toxicity related to immune-checkpoint inhibitors (ICPi) potentially resulting in significant morbidity. Early diagnosis and optimal management are essential and frequently necessitate inpatient hospital treatment. We have previously reported an ambulatory management pathway for ICPi-induced ACTH deficiency in 4 patients. We sought to report the outcomes of this pathway in a larger c...

Introduction: Pachydermoperiostosis (primary hypertrophic osteoarthropathy, PHOA) is a rare genetic condition characterised by digital clubbing, pachydermia, hyperhidrosis, cutis verticis gyrata and periostosis. The SLCO2A1 transporter and HPGD enzyme genes play an important role in prostaglandin metabolism, hence loss of function mutations in them causes PHOA. To date, according to the VarSome database 101 and 41 variants have been identified in the SLCO...

Introduction: Transgender women on gender-affirming hormone therapy (GAHT) with estrogens and anti-androgens have low serum androgen levels. These low levels may be associated with clinical symptoms such as depressed mood, reduced sexual desire and tiredness. Whether androgen levels change over the course of anti-androgen use and after gonadectomy, in a context of unchanged estrogen treatment, remains to be elucidated.Methods: This study is part of the E...

Purpose: To evaluate the value of early postoperative growth hormone (GH) as a predictor of surgical remission of acromegaly.Methods: We conducted a retrospective search through our database of patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma from 2011 to June 2022. Only patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The surgical remission was defin...

Background: Men with obesity often have low total and, with increasing adiposity, also free testosterone (T) levels, which can partially restore when they lose weight. Although this is in part explained by lower sex-hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not fully unraveled whether changes in androgen metabolization contribute to this phenomenon.Aim: Investigating metabolisation of sex steroids d...

Background: Men with obesity often have low total and, with increasing adiposity, also free testosterone (T) levels, which can partially restore when they lose weight. Although this is in part explained by lower sex-hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not fully unraveled whether changes in androgen metabolization contribute to this phenomenon.Aim: Investigating metabolisation of sex steroids d...

Background: During IVF treatment, a pharmacological dose of recombinant FSH (rFSH) is used to induce multi-follicular growth (controlled ovarian stimulation; COS). An insufficient dose of rFSH negatively impacts the number of oocytes retrieved, whereas an excessive dose risks the potentially life-threatening complication ‘ovarian hyperstimulation syndrome’. Hence, appropriate rFSH dosing is regarded as a key treatment decision affecting both the success and safety of...

Background: During 2017–2018 the diabetic team at our Foundation Trust participated in the RCPCH diabetes quality improvement collaborative to support work in reducing the mean HbA1c of our patient cohort. It is widely acknowledged that a consistent approach is vital in working towards HbA1c targets. One area of focus of our quality improvement work was to standardise the management of hypoglycaemia. As a team we decided to follow the BSPED hypoglycaemia guideline (2016) ...

Background: The adrenocortical carcinoma (ACC) is a rare malignancy with poor outcomes and overall survival of less than 40%. Different prognostic factors were evaluated in patients with ACC. We analyzed overall survival (OS) and recurrence-free survival (RFS) in patients with ACC depending on Ki-67 and ENSAT staging.Methods: We performed a retrospective study on 62 ACC patients treated at the Croatian Referral Center for adrenal gland disorders from 200...