Endocrine Abstracts

Introduction: Autoimmune forms of hypoglycemia are uncommon. However, they should be considered in any patient with hyperinsulinemic hypoglycemia. Here we present a case of persistent hyperinsulinemic hypoglycemia caused by insulin receptor antibodies.Case report: A 65-year-old chinese woman with mixed connective tissue disease (MCTD) and hypothyroidism presents with a 2-week history of persistent hypoglycemia since discontinuation of her immunosuppresan...

Objectives: Huge 9.0 magnitude quake and tsunami attacked eastern areas of Japan, on March 11th 2011. They claimed more than 20,000 lives and destroyed the nuclear power plants. Although the property damage was very little in Tokyo, about 250 miles apart from the epicenter, the people in capital faced a lot of hard situations. For example, unusual food supply, the lack of the daily necessities, the limitation of the electricity supply, and a fear of hundreds of aftershocks and...

Introduction: Type 2 diabetes (T2D) has increased in youth and complications rates may be higher than type 1 diabetes (T1D).Aims: To estimate the prevalence of complications and hypertension in youth with type 2 diabetes and compare complication rates between T2D and T1D.Design and methods: Systematic review and meta-analysis of observational studies, analysed with random effects models.Data sources: Medline ...

The aim was to evaluate the space of hyperhomocysteinemia presence with depression and diabetic nephropathy (DN) in diabetic mellitus type 1 (DMT1) patients.Materials and methods: it was examined 147 patients with DMT1 (57.1% of males, 42.9% - females) and duration of disease was 11.17 [9.07;12.26] years. Moderate age was 40.08 [30.44; 48.79] years. DN of 3–5 stages was diagnosed in 43 patients (29.3%). To provide analysis it used blood serum creati...

Introduction: Vascular complications are the leading cause of morbidity and mortality in T2D. Hypertension and/or microalbuminuria predict renal and cardiovascular outcome. This large pooled analysis from a global development program aimed to evaluate the safety and efficacy of linagliptin in this particularly high-risk population.Methods: Data of 1982 pts from 3 randomized, double-blind, placebo(PBO)-controlled phase 3 trials were analyzed. Pts with mic...

The kisspeptin, the peptide product of KiSS-1 gene has recently emerged as essential gatekeeper of pubertal activation of gonadotropin-releasing hormone neurons and the reproductive axis. Mutations or targeted disruptions in the gene cause hypogonadism or premature sexual development and sterility.Purpose: The study was undertaken to research the kisspeptin levels in healthy girls and girls with endocrine and gynaecological disorders.<p class=...

Background: Premature ovarian failure (POF) is a complex disorder defined as the cessation of ovarian function before or at the age of 40. Although the etiology of POF remains unknown in a large proportion of cases, it has been suggested that variations in the Inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic POF in a Korean population.</...

Background: Several studies have shown that medical radiation exposure in childhood might cause alteration in body composition, although all such studies were of a small scale and individual radiation doses were not estimated.Objective: The aim of this cross-sectional study was to evaluate whether or not atomic-bomb (A-bomb) radiation exposure is associated with alteration of body composition using dual energy X-ray absorptiometry (DXA).<p class="abs...

Background: Mutations in POU1F1/PIT1 gene, a pituitary-specific transcription factor, affect the development and function of the anterior pituitary and lead to combined pituitary hormone deficiency (CPHD).Objective: The clinical and genetic analysis of the twin patients presenting with mild form of CPHD and functional characterization of identified mutation.Cases: Five-year-old identical twin brothers were referred to determine the...

Introduction: Active acromegaly is associated with increased mortality, which has been attributed largely to cardiovascular disease.Aims: To evaluate the effects of chronic excess of GH and IGF1 on lipid metabolism in patients with active acromegaly.Subjects and methods: Ninety-seven patients (37 men and 60 women; aged 18–76 years) with macroadenoma of hypophysis (67 – somatotropinoma, 30 – somatomammotropinoma) were...