Endocrine Abstracts

Background: The serum concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Pregnancy is associated with increases in plasma lipid profiles. Identifying the genetic determinants could provide novel insights into mechanisms of dyslipidemia and reveal avenues for developing new therapies. The objective of this study was to investigate the impact of six single nucleotide polymorphisms (SNPs) on serum lipid levels during pregnancy.<p ...

Introduction: Chronic inflammation has been found to play an important role in the development of cardiovascular risk factors and erectile dysfunction (ED). Metabolic syndrome (MS) is associated with endothelial dysfunction and higher cardiovascular risk. The end point of this study was to investigate the prevalence of metabolic syndrome in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone leve...

A 21 years old man had growth failure since 11 y.o., micropenis, high-pitched voice, the absence of secondary sex characteristics and male sexual behavior, constant fatigue and weakness. The boy was born in time after 1st normal pregnancy, birth weight 3000 g, length 57 cm, had unilateral cryptorchidism (surgical treatment in 2002). At the age of 21 the height of the patient was 144 cm (SDS - 4.62), BMI 15 kg/m2 (BMI SDS −3.89), Tanner G1P1, bone age 13 y.o. I...

Introduction: Elephantiasis nostras verrucosa (ENV) is a rare, chronic, deforming disorder characterized by hyperkeratosis and papillomatosis of the epidermis with underlying woody fibrosis of the dermis and subcutaneous tissue resulting from chronic nonfilarial lymphoedema. Lymphatic obstruction can be primary or due to various causes such as surgery, tumour, radiation, congestive heart failure or obesity. However, to the best of our knowledge, it has not been reported as a p...

Introduction: We describe a monozygotic twin pair, of which one boy was diagnosed with anorchia. Both were followed-up till age 17.Case report: At birth, in one twin 46 XY boy (A), testes were not palpable while his brother (B) was unaffected. Stimulation with human chorionic gonadotrophin (hCG) and orchidopexia were unsuccessful at age 3. A second hCG-stimulation test was performed at age 8, where serum testosterone response failed to increase. No testi...

Introduction: Refined carbohydrates which substitute the staple diet in most cultures may exaggerate postprandial responses in term of insulin and free fatty acid levels. These changes may herald the onset of metabolic syndrome and diabetes among those at high risk of these diseases.Objectives: To determine the postprandial insulin and free fatty acids levels in healthy subjects after the consumption of two different breakfast meals, Mediterranean-like v...

Background: Diabetic nephropathy represents one of the most common causes of end-stage renal disease. During pregnancy it is associated with an increased perinatal morbidity as a striking result of the consistently high rate of preterm deliveries, mainly due to the frequent development of pre-eclampsia.Aim: To describe pregnancy outcome in type 1 diabetic women with normoalbuminuria, microalbuminuria, or diabetic nephropathy after implementation of an in...

Background: Diabetic nephropathy (DN) represents the leading cause of end-stage renal disease (ESRD). It is known that patients with ESRD have the highest risk of cardiac morbidity and mortality. Thus, identifying and treating risk factors associated with cardio-vascular disease in diabetes may offer the best approach for preventing and delaying adverse renal and cardiovascular outcomes.Aim: To determine the relationships between metabolic syndrome (MS),...

Objective: Nephropathy is a common complication in diabetes mellitus (DM), with significant morbidity and mortality. Diabetic nephropathy (DN) is more likely to develop in the presence of some risk factors associated with type 2 diabetes mellitus, even in newly diagnosed diabetics.Aim: To study the incidence of diabetic nephropathy in newly diagnosed type 2 diabetics and to study the relationship of development of nephropathy with various risk factors as...

Aims: We investigated the association between urinary pentosidine concentration (UPC) and vascular complications.Methods: UPC was measured in 66 patients (31 men and 35 women) with type 2 diabetes. We compared UPC between patients with and without diabetic microangiopathy, and between patients with and without macroangiopathy (cerebral infarction (CI), coronary artery disease, and peripheral arterial disease). Stepwise regression analysis was performed t...