Endocrine Abstracts

Aim: The aim of the present study is to determine the effects of the diabetes mellitus (DM) treatment regimens on malignancy retrospectively.Material-Method: 655 DM patients were enrolled in this study. Patients receiving diabetes therapies for at least one year were assessed with physical examination, detailed medical and family history, habits, demographic characteristics and laboratory tests and divided into two groups according to the diabetes treatm...

Probucol is a traditional anti-hyperlipidemic agent harboring marked antioxidant activity. While probucol is highly hydrophobic, its succinic acid ester, succinobucol, was reported as a water-soluble derivative and was in clinical trials. Succinobucol was shown to be more potent in lipid-lowering, anti-inflammatory and anti-atherogenic effects than probucol in animal models. In addition, succinobucol reduced HbA1c in diabetic patients. Although the clinical trials finally ende...

Introduction: Aim is to determine vitamin D level in patients with Type 2 DM and to evaluate the relationship between vitamin D level and glycemic control.Methods: We evaluated 107 women and 63 male patients with Type 2 DM whose mean age was 55±0.81. Patients fasting blood glucose (FBG), postprandial blood glucose (PPBG), HbA1c and 25(OH)D3 level were measured. The cases were divided into three groups according to measured 25(OH)D3 level (Vitamin D ...

Introduction: Our aim was to collect demographic data of diabetes mellitus (DM) patients to determine the patients education, follow-up and treatment priorities.Material-Method: 500 patients with diagnosis of DM followed up at least 6 months were included the study. Datas containing patients demographic characteristics, treatment modalities, biochemical parameters were retrospectively reviewed. On the day of admission patients; fasting blood glucose (FBG...

Estrogen excess is a major contributing factor to the development and progression of post-menopausal Estrogen Receptor positive (ER+) breast cancers. Increased activity of aromatase, the enzyme that converts androgens to estrogens, and upregulation of its encoding gene CYP19A1 is often observed in breast adipose fibroblasts (BAFs) surrounding ER+ tumours. Understanding the process by which CYP19A1 is regulated between normal and diseased breast stroma may help to improve outco...

Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour syndrome characterized by the development of tumours of the parathyroid, anterior pituitary and pancreatic islets, etc. Heterozygous germ line mutations of MEN1 gene are responsible for the onset of MEN1. Here We reported totally 87 patients from 24 unrelated Chinese families associated with MEN1 and identified five novel mutations and several previously reported mutations. Furthermore, we detected a loss of het...

Multiple endocrine neoplasia type 1 (MEN1) is a relatively rare autosomal dominantly inherited condition characterized by hyperplastic and neoplastic disorders of endocrine organs such as the parathyroid, anterior pituitary and gastroenteropancreatic endocrine tissues. Germline mutation of the causative gene, MEN1, which localizes to human chromosome 11q13 and encodes the 610 amino-acid nuclear protein menin, can be identified in most affected subjects. MEN1 gene mutation anal...

The purpose of the present study was to elucidate expressions of ERβ1 and ERβ2 expression in papillary thyroid cancer (PTC). ER β splicing variants expressions were examined on formalin-fixed, paraffin-embedded thyroid tissues from 106 PTCs and 30 nodular thyroid goiters (NTGs) by immunehistochemical methods using Elivision plus two-step system. There was significant difference in the subcellular localization of ERβ1 expression (P<0.001), but not...

Introduction: The adrenal glands are paired organs neuroendocrine, formed by the adrenal cortex and medulla, two distinct structures for histology, function, and embryological origin. The processes that most frequently affect the adrenals are adenomas 81.8%, 11.8% cysts, metastases, 11.8%, 5.9% carcinoma, pheochromocytoma 2.9%, 2.9% adrenalitis. 20–40% of adrenal masses are afuncionantes and/or discovered incidentally (incidentalomas) scans during abdominal imaging.<p...

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includ...