Endocrine Abstracts

Introduction: Thyrotoxicosis is a common condition referred to endocrine clinics. However, not all of them needed treatment with antithyroid medications. We report a case of thyroid hormone resistance due to a novel TSHRβ mutation who has been treated with subtotal thyroidectomy and antithyroid medications due to raised T4 levels.Case report: A 38-year-old south Asian woman was seen in orthopaedic clinic for elective right foot scarf oste...

Chronic inflammation in adipose tissue contributes to obesity-related insulin resistance. The 3-Phosphoinositide-dependent Protein Kinase 1 (Pdk1)/forkhead transcription factor (Foxo1) pathway is important in regulating glucose and energy homeostasis, but little is known about this pathway in adipose tissue macrophages (ATMs). To investigate this, we generated transgenic mice that carried macrophage/granulocyte-specific mutations, including a Pdk1 knockout (LysMPdk1-/-), a Pdk...

Primary hyperaldosteronism is a common cause of secondary hypertension. Distinguishing between the two subtypes (unilateral aldosterone-producing adenoma and bilateral idiopathic hyperaldosteronism) is crucial for patient’s management. Adrenal venous sampling is an important method for evaluation of the condition, but selective successful right adrenal venous sampling is often reported to be a difficult procedure. A retrospective review of 51 cases suffering from primary ...

Introduction: Calcium transport is regulated by active transcellular and passive paracellular pathways which are responsible for calcium (re)absorption in the intestine and kidney. The activity of passive transport is determined by the permeability of tight junction. In general, the permeability of tight junction is inversely proportional with the expression of tight junction genes. Claudin and occludin among the tight junction genes are concerned directly with permeability of...

Abundant evidence demonstrates that long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous study shows a significant association between IL4 genotypes and T2DM, as well as between IL4 genotypes and the lower circulatory levels of high-density lipoprotein-cholesterol (HDL-C). In addition, IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance as well as being involved in lipid m...

Aim: Gallstones are associated with excess body fat. Our aim was to evaluate lipid levels and markers of oxidative stress in subjects with asymptomatic gallstones.Material and method: Eighty subjects (55 females, 25 males) with a mean age±S.D. of 51±14 years with asymptomatic gallstones were admitted to the study. Forty subjects (25 females, 15 males) with a mean age±S.D. of 57±12 years (P<0....

Objective: The aim of the present study was to determine the plasma osteoprotegerin (OPG) levels in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during the last trimester of pregnancy, and to investigate the relationship between OPG and some related factors.Method: In this study, 65 women with GDM and 65 women with NGT were enrolled. Plasma concentration of OPG was measured by enzyme linked immunosorbent assay (ELISA)...

Background: Many in vitro studies have suggested that oxidative stress induced by hyperglycemic condition has pivotal role for pathogenesis of vascular complications in diabetics. This study intended to evaluate oxidative stress and antioxidant potential in patients with type 2 diabetes mellitus (DM), and to clarify the relation between oxidative stress and metabolic derangements including chronic hyperglycemia.Materials and methods: We measured t...

Aim: To study character of neuroendocrine disorders in children and adolescents with the Turkish saddle volume formations.Materials and methods: we examined 35 children and adolescents, 17 girls and 18 boys among them with the Turkish saddle volume formations at the neuroendocrine department of the Center for the scientific and clinical study of endocrinology. All examinees underwent general clinical examination as well as biochemical and hormonal invest...

The reproductive system is controlled by (GnRH) secretion from the brain, which is finely modulated by a number of factors, including gonadal sex steroids and inhibins. It was recently claimed that kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion. Therefore, we have developed highly specific and sensitive fluoro-immunoassays (FIAs) using Eu-labeled antigens for KP 10 and GnIH. In this study, the distributions of KP 10 and GnIH...