Endocrine Abstracts

Introduction: Cushing’s syndrome is rare during pregnancy perhaps because hypersecretion of glucocorticoids supresses pituitary gonadotrophin secretion resulting in subfertility. When present, the syndrome is usually due to adrenal disease and less commonly to pituitary adenomas or ectopic ACTH production. In the contrary, Cushing’s syndrome outside pregnancy is usually due to pituitary adenomas whereas non ACTH-dependent Cushing’s is less frequent.<p class=...

Aim: To study clinical–epidemiological peculiarities of diabetic macroangiopathies in diabetes mellitus (DM) and diabetes insipidus (DI) combination.Materials and methods: We examined 2208 cases of DI registered in the RUz in 2006–2010, 106 DM–DI combinations among them. DM–DI combination prevalence, calculated for 100 000 of adult and infant population, was assessed analysis of data on patients registered at the endocrine ambulances....

Aim: To evaluate influence of cabergoline on LAO and BAS processes in treatment of patients with NFPA.Materials and methods: We included 64 patients with NFPA in the study. Mean age was 43.6±3.84 years (range 30–55 years). Of 64 patients 26 (40.6%) were men and 38 (59.4%) were women. Duration of the disease from diagnosis based on MRI constituted 1–15 years. Severity criteria used in the evaluation were LH, FSH and prolactin (PRL) growth a...

Objective: To evaluate the reliability of GH stimulation tests in multiple pituitary hormone deficiency (MPHD) and isolated GHD.Materials and methods: In 19 children with MPHD, we analysed the results of insulin tolerance test (ITT), clonidine and sleep tests, anthropometric parameters, IGF1, bone age, pituitary hormone levels±MRI. GH provocation tests were repeated after variable periods, mostly 6–24 months. The GH provocation tests were consi...

Introduction: Primary hyperparathyroidism affects 1% of the world’s population, with majority of cases due to benign parathyroid adenomas. Parathyroid cancer is a rare cause.Case report: This case report describes a 53-year-old lady presenting with nonspecific bone pains, whose initial workup revealed mild hypercalcemia and MRI lumbosacral spine suggestive of multiple myeloma. Subsequent work up, including two bone marrow examinations and serum prot...

Background: It is well known that care must be taken in initiating testosterone replacement in individuals with historically low androgen levels. However less is reported about the influence of restoration of normal endogenous testosterone production on behaviour.Here, we report the how adverse sequelae of successful treatment of secondary hypogonadism were managed through a joint approach.Case report: A 34-year-old Business Accoun...

17β-hydroxysteroid dehydrogenase-3 (17βHSD3) deficiency is an autosomal recessive form of male pseudohermaphroditism due to impaired testicular conversion of androstenedione to testosterone. 46,XY homozygotes or compound heterozygotes for mutations of the HSD17B3 gene have testes and normally developed Wolffian duct derivatives, but they present with undervirilization of the external genitalia, which are often female. About twenty different mutations of the 17βH...

The aim of the study: An attempt to assess relative roles of common risk factors of coronary artery disease (CAD) and sex hormones in the pathogenesis of CAD in young menstruating women (W).Materials: CAD-W group: 52 W in the age of 38–48 years with angiographically proven critical changes in coronary arteries. 38 of them suffered from myocardial infarction. H-W group: 15 healthy W in the age of 35–45 years.Methods: In al...

Aim: To assess possible changes in concentrations (conc) of hormones in men (M) suffering from metabolic syndrome (MS) which may be involved in pathogenesis of coronary artery disease (CAD).Materal: CAD-M group: 33 M with MS and CAD in the age 51,5±6,4 years with angiographically defined CAD. 14 of them were normoglycemic, 19 with impaired glucose tolerance or diabetes mellitus t. II. H-M group: 13 healthy M in the same age.Me...

Aim: To assess hormonal function of cortex of adrenal glands in patients (pts) after cardiac arrest (CA) and its role for survival.Material: CA-pts- 52 pts after CA in the age 62±13 years. 26 pts died after CA (CA-D-pts), 26 pts survived and were discharged from hospital (CA-S-pts). H-pts- 22 pts in the age 60±11 years with stable coronary artery disease.Methods: In CA-pts concentrations(conc) of adrenocorticotropin (ACTH...