Endocrine Abstracts

Graves’ Disease (GD) affects about 2% of the population in the UK, with female predominance. A proportion of GD patients (5–50%) develop orbitopathy (GO), which is characterized by tissue remodeling in the orbit leading to protrusion of the eye (proptosis). Blood biomarkers associated with GD or GO could be useful diagnostic or prognostic tools for researchers and clinicians. Within the framework of INDIGO IAPP-612116 (Investigation of Novel biomarkers and Definition...

BackgroundHormone replacement therapy is often used for hypopituitarism, which leads to dysglycemia. This study is conducted to assess the glucose metabolism conditions using the flash glucose monitoring system (FGMS) in patients with hormone replacement therapy.MethodSeven patients who were diagnosed as hypopituitarism and treated with glucocorticoids and L-Thyroxine were qualified to participate in this stu...

Background: Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing’s syndrome. The clinical application of adrenal venous sampling (AVS) in diagnostic work-up for PBMAH is still controversially discussed. AVS might be useful in evaluating the predominant side and guiding the decision for unilateral adrenalectomy in PBMAH.Objectives: Our aim was to evaluate whether certain metabolites in AVS samp...

Objectives: We previously reported the outcome of 1-year follow-up of 2013 DTC patients in the DTCC (differentiated thyroid cancer in China) 1st stage Study. Using the retrospectively gathered information, we sought to observe the long-term follow-up and prognosis of these patients with DTC undergoing thyroid surgery.Methods: This multicenter, noninterventional study was conducted at eight tertiary hospitals across China. Data from the patient...

High protein diets are hypothesised to improve glucose tolerance by modulating the secretion of gastroenteropancreatic hormones via amino-acid sensing. Glucagon, traditionally associated with hyperglycaemia, has beneficial effects on glucose homeostasis, potentially due to its role as an insulin secretagogue via intra-islet signalling and as a regulator of pulsatile insulin secretion. The calcium sensing receptor (CaSR), known for its role in calcium homeostasis, also function...

Background: G3NETs demonstrate variable clinical behavior (Ki-67>20-100%). Treatment extrapolated from grade 1/2 (G1/2) NETs and neuroendocrine carcinomas depending on clinicopathologic features. Therapy for treatment-emergent G3NETs remains especially ill-defined.Methods: Retrospective chart review of patients with de novo G3NETs or progressing from low-to-high grade (L-H) (G1/2 at diagnosis and G3 >=3 months later). Treatment patterns compared ...

Background: Expected progression free survival (PFS) for patients with grade 3 well-differentiated neuroendocrine tumors (WD NET) treated with peptide receptor radionuclide therapy (PRRT) is approximately 9 months, and objective response rate (ORR) is 35%. Response rate to single agent immune checkpoint inhibitors (ICI) for patients with G1-3 NET is <15%. Delivery of targeted radiation using PRRT may potentiate the anti-tumor immune response. The purpose of this study is t...

ImportanceThere remains uncertainty about the impact of menopausal hormone therapy (MHT) on women’s health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking.ObjectiveTo comprehensively summarize evidence on the benefits and harms of MHT across diverse health outcomes in women.Data sourcesMEDLINE, EMBASE and 10 other databa...

Background: Benign adrenal tumours are discovered in 3-10% of adults and can be non-functioning (NFAT) or associated with adrenal hormone excess, most frequently mild autonomous cortisol secretion (MACS) defined by the failure to suppress cortisol after 1 mg dexamethasone overnight but lack of distinct signs of Cushing’s syndrome (CS). We found that MACS increases the prevalence and severity of type 2 diabetes and hypertension and primarily affects women (Ann Int Med. 202...

: Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) form a group of enzymes that are characterized by their sequence similarity at the active site, and their ability to catalyze the conversion between the weak 17keto- and the highly active 17beta-hydroxysteroids. To study the physiological role of HSD17B13, a lipid droplet associated protein, we characterized the phenotype of knockout (KO) mice deficient in HSD17B13 (HSD17B13KO). The data revealed normal serum sex steroid conce...