Endocrine Abstracts

Replacing glucocorticoids in patients with adrenal insufficiency is challenging, as endogenous cortisol levels rise before waking. Currently we use steroid replacement first thing in the morning. Administration of a delayed release preparation last thing at night, if reliable, could mimic the rise in cortisol that occurs before waking. Lodotra is a modified release prednisone that has a delay in the onset of action, and when given last thing at night, might cause a rise in lev...

Once daily oral prednisolone has been shown to mimic the normal circadian rhythm better than other glucocorticoids. Our advice is to take prednisolone first thing on waking and before breakfast to try to mimic the normal circadian rhythm as closely as possible. The leaflet that comes with prednisolone suggests that it should be taken with food. Enteric-coated prednisolone (EC) is believed to be kinder on the stomach, but there is no evidence for its use. We compared EC with st...

Replacing glucocorticoids in patients with adrenal insufficiency is challenging, as endogenous cortisol levels rise before waking. Currently we use steroid replacement first thing in the morning. Administration of a delayed release preparation last thing at night, if reliable, could mimic the rise in cortisol that occurs before waking. Lodotra is a modified release prednisone that has a delay in the onset of action, and when given last thing at night, might cause a rise in lev...

Introduction: Primary aldosteronism (PA) is a common cause of secondary hypertension that can lead to renal sequelae. Treatment of hyperaldosteronism leads to reductions in albuminuria and glomerular hyperfiltration. We aimed to evaluate the effect of treatment on albuminuria and temporal changes in renal function after treatment with both surgery and medications.Methods: We prospectively recruited patients with PA over three years. Spot urine samples fo...

Introduction: Although the Endocrine Society guidelines recommend using aldosterone: renin ratio (ARR) to screen patients for primary aldosteronism (PA), whether to include a cut-off for aldosterone levels remains controversial. In Singapore, most centres require both an ARR >550 (ng/dl)/(ng/ml per h) and aldosterone ≥15 ng/dl. However, it has been shown that patients with PA may have aldosterone levels<15 ng/dl, and also respond well to mineralocorticoid antagon...

CIDEC is a lipid droplet-targeting protein that promotes triglyceride accumulation and inhibits lipolysis. CIDEC is regulated by peroxisome proliferator-activated receptor γ (PPARγ). Previous studies demonstrate that CIDEC down-regulation is involved in TNFα-induced lipolysis. Here, we focus on the signalling pathway to clarify the mechanism of TNFα-mediated CIDEC down-regulation. CIDEC is significantly decreased in subcutaneous adipose tissue in obese subj...

Background: Investigating the origin of ACTH determine disparate treatment and prognosis in ACTH-dependent Cushing’s Syndrome. We want to detect the value of combination of HDDST and DDAVP stimulation test for identifying Cushing’s disease (CD) and Ectopic ACTH-dependent Cushing’s Syndrome (EAS).Methods: We retrospectively recorded 102 ACTH-dependent Cushing’s Syndrome (87 CD and 15 EAS) in West China Hospital from January 1, 2010...

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Background: The gestational diabetes mellitus (GDM) is a metabolic disorder characterized by glucose intolerance in pregnant women without pre-existing diabetes, typically diagnosed in mid to late pregnancy. The global prevalence of GDM is on the rise, posing significant diagnostic and economic burdens on society and affecting the health of two generations, potentially impacting population quality. Early diagnosis or understanding of the pathophysiology of this disease in earl...

Objective: Some observational studies have suggested the association between thyroid function and polycystic ovary syndrome (PCOS). However, it remains to be determined whether these associations are causal or not. The aim of this study was to investigate the underlying causal association between different thyroid function status and PCOS.Methods: Bidirectional Mendelian randomization (MR) analysis was conducted to explore the impact of different thyroid...