Endocrine Abstracts

Backgrounds: Based on anthropometry and blood biochemical tests, this study aims to analyze the variation of glucose and lipid metabolism in Cushing’s syndrome (CS) patients caused by adrenal adenoma combining with flash glucose monitoring system (FGMS) and dual-energy X-ray absorptiometry (DEXA).Methods: According to the strict diagnostic and exclusion criteria, seven healthy controls (HCs) and seven CS patients were collected in this study. First,...

BackgroundsThe study aimed to explore the characteristics of glucolipid metabolism in patients with nonfunctional adrenal incidentaloma(NFAI). And investigate the relationship between these factors and insulin resistance, islet beta cell function.MethodsThis study enrolled eight patients with nonfunctional adrenal incidentaloma and five healthy controls(HCs). These data were recorded including body measuremen...

Background: Confirmatory tests, including saline infusion test (SIT), captopril challenge test (CCT) and fludrocortisone suppression test (FST) are commonly used for diagnosis of primary aldosteronism (PA). Each test has its advantages and disadvantages, but which one should be preferentially performed is controversial. We aimed to evaluate the diagnostic accuracy of three tests in a prospective study.Methods: Five hundred and thirty-one hypertensive pat...

Glycyrrhizin (GL) is a major bioactive triterpene glycoside of licorice root, a traditional Chinese herbal medicine. GL and primary metabolite 18β-glycyrrhetinic acid (GA) have been developed as anti-inflammatory and antiviral drugs for liver diseases in China and Japan. Hepatic VLDL secretory pathway is not only responsible for lipid homeostasis but also associated with viral particles assembly and secretion. Hepatocyte nuclear factor 4α (HNF4α) together with i...

Accumulating clinical data suggest that women with polycystic ovary syndrome (PCOS) are at high risk for nonalcoholic fatty liver disease (NAFLD). However, it is not clear whether hyperinsulinemia and hyperandrogenism act concomitantly or independently to induce hepatic steatosis and inflammation, and the molecular mechanisms behind the interactions between insulin resistance and hyperandrogenism in the female liver remain largely unexplored. To achieve hyperinsulinemia, insul...

Peripheral insulin resistance and hyperandrogenism are the primary features of polycystic ovary syndrome (PCOS). However, how insulin resistance and hyperandrogenism affect uterine function and contribute to the pathogenesis of PCOS are open questions. Rodent models of insulin and human chorionic gonadotropin (hCG) treatment have provided systems in which to study ovarian insulin resistance, ovarian stromal hyperplasia, follicular cyst formation, and impaired mitochondrial fun...

Summary: Objective: To evaluate the expression level and binding affinity of glucocorticoid receptors (GRs)in patients with endogenous Cushing’s syndrome(CS) and to determine whether there is partial glucocorticoid resistance.Methods: Fifty-eight patients with CS and forty-one age- and sex-matched healthy volunteers were studied. The expression level and binding affinity of GRs in peripheral blood mononuclear cells (PBMLs) were examined by flow cyt...

The question posed by this title encompasses three issues. First, certain endocrine diseases present physiologic challenges to high-intensity or endurance activities, including type 1 diabetes mellitus and adrenal insufficiency. Using carefully adjusted insulin regimens evolved in concert with training sessions, several athletes with type 1 diabetes have succeeded in elite competitions, but the endocrinologist must ‘train with the athlete’ and craft regimens that con...

Thyrotropin receptor (TSHR, signals via CREB) expression increases during adipogenesis, a process occurring in Graves’ orbits. CREB activation has been reported ‘necessary and sufficient’ to induce adipogenesis. However, we previously demonstrated that expression of constitutively active TSHR in orbital preadipocytes stimulated early but inhibited later differentiation stages, even when PPARγ agonist induced. Overproduction of proteoglycans is also a featur...

Background: CB1 antagonism has potential benefits in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and peripheral action on adipose tissue. We have previously demonstrated the inhibitory effects of CB1 inactivation on preadipocyte proliferation and now extend these studies to in vitro adipogenesis.Aims: To compare the effects of CB1 agonism and antagonism on differentiation in both preadipocyte cell lines and ...