Endocrine Abstracts

Background: Patients with neuroendocrine neoplasms (NENs) have a high burden of chronic symptoms. We assessed symptom burden and overall quality of life (QOL) for eNET study participants and analyzed differences by age, sex, and NEN primary site.Methods: eNET is a prospective, cohort study on the Eureka digital health platform enrolling individuals with advanced NENs. Participants completed validated surveys on an internet-supported device at baseline an...

Background: Pituitary neuroendocrine tumors (PitNETs) exhibiting treatment-refractory behavior are the rare subset that progress after radiation and are characterized by unrelenting growth and metastatic dissemination.Methods: To identify biomarkers of treatment-refractory behavior, two groups of patients with PitNETs were consented to matched tumor-normal whole exome and targeted next-generation DNA sequencing on a clinical protocol: a prospective group...

Major adverse cardiac events (MACE) are the leading cause of death among hip fracture patients. This study aimed to: (1) identify hip fracture subphenotypes using LCA and (2) evaluate the prognosis of the hip fracture subphenotypes on CVE-related outcomes in two extensive hip fracture cohorts from Hong Kong (HK CDARS; n=78,417) and the United Kingdom (UK THIN; n=27,948), employing both the conventional cohort (between-individual comparison) design and the sel...

Background: Acromegaly is a rare disorder characterized by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Extended dosing intervals (EDIs) of pharmacological treatments may reduce patient burden and costs compared with standard dosing. This systematic literature review (SLR) investigated treatment of acromegaly at EDIs.Methods: MEDLINE/Embase/the Cochrane Library (2001–June 2021) and key congresses (2018–2021) were searche...

Introduction: Atherosclerosis is a chronic inflammatory arterial disease and is currently one of the most common causes of cardiovascular morbidity and mortality worldwide. Therefore, there is an urgent need to discover new therapeutic targets for treatment of this fatal chronic disease. Fatty acid binding protein 4 (FABP4), a pro-inflammatory adipokine that links obesity with its related metabolic diseases, has been implicated in the development of atherosclerosis. This study...

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism in women, with a high incidence of insulin resistance. Decanoic acid (DA), a naturally occurring 10-carbon fatty acid, has been shown to improve insulin sensitivity and lipid profile in an in vivo model of diabetes without the induction of weight gain. However, the effects of DA on androgen production has not been explored.Aim: The objective o...

Introduction: The effects of mild subclinical hypothyroidism (SH; TSH <10 mU/l) on metabolic outcomes are unclear. This may relate to differences in aetiology, including thyroid autoimmunity or genetic factors such as TSH-receptor mutations (TSHR-M) and FOXE1 polyalanine tract length (FOXE1–PTL) polymorphisms, which are associated with altered thyroid function. We hypothesised that the metabolic manifestations of SH may depend upon its aetiology.<p class="abstext"...

Background: Data examining HLA associations in Addison’s disease (AD) from South Africa (SA) are limited. We wished to determine the HLA in South African AD patients either positive or negative for 21 hydroxylase autoantibodies (21 OH-AA) and matched healthy controls, hypothesising that certain HLA alleles could predominate, but there may be differences from Western countries.Methods: SA patients (n=73) were enrolled as part of a nationwide...

Background: To investigate the typing for HLA-I in Chinese patients with type 1 diabetes (T1D) as a complement screening for HLA-II.Methods: A total of 212 T1D patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA-I and II were examined with a high-resolution polymerase chain reaction-sequence-based typing method.Results: The novel haplotype, A*33:03-B*58:01-C*03:02(A33), was a...

Bile acids (BAs) are synthesized by converting cholesterol in hepatocytes and recycling it via enterohepatic circulation. Most BAs are reabsorbed into hepatocytes, where they inhibit their own synthesis by activating FXR pathway. NTCP is a major transporter of BAs via absorption from portal blood into hepatocytes. Hepalatide is a 47aa synthetic peptide that specifically binds NTCP resulting in BA spillover of hepatocytes into the systemic circulation. In this way, BA synthesis...