Endocrine Abstracts

Patients with the syndrome Resistance to Thyroid Hormone (RTH) exhibit purturbances in regulation of serum thyroxine and often suffer from hypermetabolism, tachycardia, hyperactivity and mental retardation. Most of these patients express a mutant thyroid hormone receptor beta (TRb) unable to bind ligand, resulting in transdominant negative effects in transcription. As no patient with a mutant TRa has been identified, we introduced into the mouse TRa1 gene a point mutation foun...

Björn Vennström, Karolinska Institute, Stockholm, Sweden AbstractBjörn Vennström obtained his PhD at Uppsala University in 1978. He then spent two years in Dr Michael Bishop's laboratory at UCSF, characterising the erbA and erbB proto-oncogenes. Back in Uppsala he showed that the v-erbB oncogene of the Avian Erythroblastosis Virus is necessary and sufficient for transformation of both hematopoetic ...