Endocrine Abstracts (2001) 2 P79

IMPROVEMENT OF MALE HYPOGONADISM IN SEVERE OBESITY DURING WEIGHT LOSS AFTER BARIATRIC SURGERY

M Monteiro1, H Cardoso1, G Vargas1, P Mendes1, A Sergio2, M Santos3, C Santos3 & H Ramos1


1Dept of Endocrinology, Hospital Geral Santo Antonio, Porto, Portugal; 2Dept of Surgery, Hospital Geral Santo Antonio, Porto, Portugal; 3Dept of Pathology, Hospital Geral Santo Antonio, Porto, Portugal.


Objectives: To evaluate changes in gonadotrophins, total (TT) and free (FT) testosterone, SHBG, insulin and c-peptide levels during weight lost after bariatric surgery.

Material and methods: Seven (n=7) patients submitted to bariatric surgery for treatment of severe obesity were followed-up over time. Before surgery mean age was 32,857 (19-56) years old, mean weight was 170,571 kg (± 37,362) and mean BMI was 58,824 kg per m2(± 14,211).

Results: After a mean follow-up of 13 months (min 6, max 25), mean weight and BMI decreased respectively to 126 kg (min 97, max 196; ± 33,872) and 43,767 Kg per m2 (± -13,845).

The mean analytical values before (B) and after (A) surgery were: FSH (mUI per ml) B:3,245 ± 1,380 A:2,330 ± 0,948; LH (mUI per ml) B:3,142 ± 0,780 A:2,700 ± 1,009; TT (ng per ml) B:2,050 ± 0,825 A:3,653 ± 1,452; FT (pg per ml) B:6,028 ± 2,377 A:13,400 ± 5,702; SHBG (nmol per l) B:21,237 ± 15,329 A:26,666 ± 10,366; Insulin (microunits per ml) B:44,528 ± 39,321 A:17,716 ± 12,1598; C-Pep (ng per ml) B:6,833 ± 2,320 A:4,116 ± 1,621.

After surgery all patients improved their weight and BMI in a significant way (p=0,001). Weight loss attained with bariatric surgery resulted in significant increase of TT and FT (p=0,019 and p=0,026), and decrease of c-peptide (p=0,034). Gonadotrophins and SHBG increased and insulin decreased, with weight loss, but not significantly.

Conclusions:

Weight loss in men with severe obesity and hypogonadism, attained by bariatric surgery, improved hypogonadism with increase of TT and FT levels.

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