Endocrine Abstracts (2002) 3 P110

Intensive insulin therapy in diabetic pregnancy

OV Safonova

Department of Endocrinology, Medical University of Lviv, Lviv, Ukraine.

For realisation of Sent-Vinsent declaration we organised the group of diabetic pregnant women for observation. 32 patients were examined. Besides common clinical and biochemical examination we conducted measurement of plasma circulation immune complexes (CIC) levels. The control group comprised 10 normal pregnant women. Normal pregnant state: CIC level was 169,64 ±2,93 u.o.s.

In diabetic pregnant state with decompensation stage CIC level was 450,77 ± 15,37 u.o.s. (p<0,001). Using of intensive insulin therapy with reaching of compensation stage conduct to decreasing of CIC level: 224,88 ± 17,56 u.o.s. (p<0.001).

Increasing CIC level in diabetes mellitus, which damage a vessel walls, could witness about accelerated development of diabetic angiopathies, separately in placenta. The is established decreasing CIC level after intensive insulin therapy. This retards development of diabetic microangiopathies and helps of better function of placenta.

Introduction of intensive insulin therapy method in the treatment contributed to decreasing perinatal pathology and mortality on 6%.

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