Endocrine Abstracts (2002) 3 P160

Independent Y chromosome markers associated with blood pressure and testosterone levels

FJ Charchar1, M Tomaszewski2, S Padmanabhan1, B Lacka2, NH Anderson1, E Zukowska-Szczechowska2, W Grzeszczak2 & AF Dominiczak1

1Glasgow University, Glasgow, UK; 2Department of Internal Medicine, Diabetology and Nephrology, Silesian School of Medicine, Zabrze, Poland.

Objective: To examine if there was an association between blood pressure and two polymorphic markers, M9 (CtoG) and HindIII in the non-recombining region of the Y chromosome.

Design and Methods: 204 pedigrees all including hypertensive individuals were collected from the south of Poland after local Ethical committee approval. Phenotypic data including hypertensive status as well as BP, weight and height were collected. We phenotyped and genotyped 155 unrelated males for both SNPs by RFLP. We also measured testosterone levels by radioimmunoassay. Welch's corrected t-test was used for comparisons between genotypes.

Results: There was no significant difference in age or body mass index between the two genotypes (for both M9 and HindIII) in the group. Men with the HindIII(+) genotypes had significantly higher unadjusted systolic (135±16 vs 145±25 mmHg), p=0.01) and diastolic pressures (85±10 vs 90±14 mmHg, p=0.02) than those with the HindIII(-) genotype. This difference between the two HindIII genotypes was 5.3mmHg (P=0.0014) for systolic and 2.6mmHg (P=0.0045) for diastolic blood pressure adjusted for age and BMI. There was no significant difference in blood pressures between the two genotypes of the M9 marker. However, the M9 C allele was associated with increased testosterone (15.9±9 vs 12.4±8 pg/ml, p=0.02) levels compared to the G allele. There was also no significant correlation between blood pressure and testosterone levels.

Conclusions: Our results indicate that the Y chromosome harbours a locus near the HindIII marker which contributes to blood pressure variation in men. This locus seems to be independent from a locus that contributes to testosterone levels.

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