Endocrine Abstracts (2002) 3 P2

Bone mineral density of asthmatic children after long term treatment with inhaled corticosteroids

G Ouzouni, S Bizanias, D Karakaidos, V Vovolis, G Triantafyllidis, A Nikolaidou & C Karis


Paediatric Department, General Hospital of Nikea, Piraeus, Greece.


INTRODUCTION

Twelve prepubertal children (7 boys and 5 girls) who had been continuously using I.C.S. for at least 3 to 5 years in a prescribed dose of at least 500-800 micrograms per day were included in the study. Age ranged from 4 to 11 years. Duration of I.C.S. treatment ranged from 3 to 5 years. 20 children of the same population were used as controls. Bone mineral density (B.M.D.) of the lumbar spine (L2-L4) was measured by Dual Energy X-ray Absorptiometry (D.E.X.A.)

RESULTS

Bone mineral density did not reveal significant statistical difference between the study and control group. (Table I)

B.M.D. g/cm2

Patients n=12 Controls n=20

0,802±0,225 0,832±0,209 p>0,05

CONCLUSION

Children with asthma who had been on a daily I.G.S. dosage of 500-800 micrograms for 3 to 5 years had normal B.M.D. values as their healthy controls. Long term longitudinal studies are needed to investigate whether these children attain a normal peak bone mass.

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