Serum of infertile males and that of proven fathers (n=717) was analysed for the measurement of sperm concentration, serum LH, FSH and testosterone. Earlier, when classified on the basis of sperm count, 13% males turned out to be azoospermic, 15% oligozoospermic, 0.025% polyzoospermic and 42% normozoospermic in a five year analysis. Oligozoospermic subjects were further classified as mild, moderate and severe oligozoospermic. Hormonal analysis indicated normal levels of LH and testosterone, while FSH levels were negatively correlated to the sperm concentration, suggesting Sertoli cell dysfunction to be the cause of azoospermia and oligozoospermia among the studied subjects. Serum of azoospermic (n=65) and oligozoospermic (n=170) men was also analysed for chemical pathology, to observe the relationship between the infertile state and blood chemistry profiles. The study indicated that infertility does not affect other physiological parameters, as demonstrated by the results of the chemical pathology of these patients. As male factor infertility is generally considered to be a deficiency of spermatozoa, their excess goes unnoticed, although it too causes negative effects on fertility. Over a period of five years, 1201 patients were examined, and only 3 were found to be polyzoospermic (concentration more than 250 million/ml). Two of these were hypospermic (volume < 2 ml) but with all other parameters within normal range, while the third had active linear motility of 35%.
08 - 11 Apr 2002
British Endocrine Societies